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NR. 2/2004
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Wartość
diagnostyczna poziomów VEGF i PEDF dla oceny procesu
neowaskularyzacyjnego w chorobach oczu
Diagnostic value of VEGF and PEDF for evaluation of neovascular
process in ocular diseases
Jerzy Z. Nowak
Zakład Farmakologii Uniwersytetu Medycznego w Łodzi
Kierownik: prof. dr hab. Jerzy Z. Nowak |
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| Summary: |
An array of ocular
diseases result from (or are accompanied by)
neovascularization. They include, among others,
retinopathy of prematurity, diabetic retinopathy or
age-related macular degemneration. The process of
neovascularization is developing under condition of a
functional dominance of proangiogenic factors over
antiangiogenic ones. Vascular endothelial growth factor
(VEGF) is a key stimulator of angiogenesis, while a
recently discovered pigment epithelium-derived factor (PEDF)
appears to be a powerful endogenous inhibitor of
angiogenesis. This paper reviews recent „human”
experimental findings showing ocular levels/concentrations
of VEGF and PEDF in various ophthalmological diseases
occurring with neovascularization. Based on literature
experimental and clinical data, a possible diagnostic/prognostic
value of increased and/or decreased concentrations of
ocular VEGF and PEDF, respectively, is discussed in
terms of both development of a given disease and
effectiveness of a given therapeutic approach. |
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| Key words: |
neovascularization, VEGF (vascular
endothelial growth factor), PEDF (pigment
epithelium-derived factor), ocular diseases. |
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