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NR. 4/2004
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Ocena wybranych
parametrów układu antyoksydacyjnego osocza u wcześniaków
badanych przesiewowo w kierunku ROP
The estimation of parameters of antioxidant system in preterm
infants ROP screening
Monika Oziębło-Kupczyk1,
Alina Bakunowicz-Łazarczyk1, Elżbieta Skrzydlewska2,
Marek Szczepański3, Krystyna Dzienis3, Ewa
Waszkiewicz2
1Klinika Okulistyki Dziecięcej Akademii Medycznej w
Białymstoku
Kierownik: prof. dr hab. med. Alina Bakunowicz-Łazarczyk
2Zakład Chemii Analitycznej i Nieorganicznej Akademii
Medycznej w Białymstoku
Kierownik: prof. dr hab. Elżbieta Skrzydlewska
3Klinika Neonatologii Akademii Medycznej w
Białymstoku
Kierownik: dr hab. med. Marek Szczepański |
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| Summary: |
Purpose: To
estimate correlation between antioxidant system
parameters concentrations in plasma in preterm infants
and appearance of ROP.
Material and methods: We examined 12 preterm
infants with the average birth weight of 1171g and
gestational age of 29.1 wk. Total antioxidant status (TAS),
reduced glutathione (GSH) and suproxide dismutase (SOD)
were measured at day 1 (cord blood), 7 and 14 after
birth. Premature infants had ROP screening. The control
group included 12 infants born at term.
Results: 4 preterm infants had retinopathy of
prematurity and higher levels of SOD, GSH and TAS than
control group but these differences were no
statistically significant.
There were no differences in concentrations of measured
parameters between 8 infants without ROP and a control
group.
Conclusions: In preterm infants who later
suffered from ROP we observed higher antioxidant
capability of plasma than control group and preterm
infants without ROP. |
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| Key words: |
retinopathy of prematurity,
antioxidants, oxidative stress. |
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