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NR. 2/2006
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Rola stresu
oksydacyjnego w patogenezie zwyrodnienia plamki związanego z
wiekiem
Consequence of Oxidative Stress in the Pathogenesis of
Age-Related Macular Degeneration
Barbara Polaczek-Krupa, Iwona
Liberek
Klinika Okulistyki Centrum Medycznego Kształcenia Podyplomowego
w Warszawie
Po. kierownika: dr n. med. Iwona Liberek |
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| Summary: |
According to the present
opinions, the effect of free radicals on cell-contained
organic compounds is one of the main etiological factors
resulting in age-related macular degeneration
development. Sources of oxygen free radicals, their
interaction with lipids, proteins, carbohydrates and
nucleic acids as well as effects of oxidation of the
organic compounds were described. In particular, the
oxidation of the polyunsaturated fatty acids contained
in external photoreceptor segment membranes as well as
the deposition of the reaction products (as lipofuscin)
in retinal pigment epithelium cells were taken into
consideration. The importance of the lipofuscin occuring
phototoxic reactions and photosensitization of
hemoglobin precursors in choriocapillaris for an
oxidative damage of retinal pigment epithelium and
photoreceptors was emphasized. The most important
chemical compounds (glutathione, carotenoids) present in
the antioxidative retina system and protecting the
retinal nerve cells against the disadvageous action of
oxygen-reactive species were also presented. |
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| Key words: |
age-related macular
degeneration, oxygen-reactive species, lipofuscin,
photosensitization, antioxidant. |
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