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NR. 3/2006
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Powikłania po
terapii fotodynamicznej z użyciem werteporfiny (PDT) oraz
fototrombozie indukowanej zielenią indocyjaninową (iMP)
stosowanych w przypadkach guzów wewnątrzgałkowych
Complications after Photodynamic Therapy (PDT) with Verteporfin
and Indocyanine Green – Mediated Photothrombosis (iMP) used in
Intraocular Tumors Treatment
Agnieszka Kubicka-Trząska, Bożena
Romanowska-Dixon, Joanna Kobylarz, Anna Piwowarczyk, Arkadiusz
Pogrzebielski, Iwona Szuścik
Klinika Okulistyki i Onkologii Okulistycznej Katedry Okulistyki
Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie
Kierownik: dr hab. n. med. Bożena Romanowska-Dixon |
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| Summary: |
Phototherapy is new and
safe method of intraocular tumors treatment.
Photodynamic therapy with verteporfin (PDT) and
indocyanine green-mediated phothothrombosis (iMP) seem
to be effective therapies for optic disc capillary
haemangiomas and posterior pole choroidal haemangiomas
as well as in selected small and medium choroidal
melanomas. These methods are effective in reducing not
only the tumor mass but they may also stabilize or
improve vision. Comparing to other methods PDT and iMP
are characterized with a relative low risk of
complications which occur in 30 - 35% of cases. The most
common complications include: haemorrhages within the
tumor mass, subretinal and intravitreal haemorrhages,
overlying branch vascular occlusion, macular edema and
preretinal fibrosis with tractions formation. In some
cases of choroidal melanomas the phototherapy leads only
to the temporary tumor regression thus its effect is not
longstanding. However this phenomenon is not observed in
vascular intraocular tumors.
Based on the literature and our own experience we assume
that both PDT and iMP are safe and low risk methods of
some cases of intraocular tumors treatment. In majority
of cases they may lead to stabilization or tumor
thickness regression as well as they may preserve or
even improve vision in affected eye. |
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| Key words: |
intraocular tumors,
photodynamic therapy with verteporfin, indocyanine
green-mediated photothrombosis, complications. |
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