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NR. 2/2007
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Wpływ ocznych kropli
ketotifenu na stężenie eozynofilowego białka kationowego we
łzach u pacjentów z alergicznym zapaleniem spojówek
Effect of Ketotifen Ophthalmic Solution on Eosinophil Cationic
Protein Concentration in Tears of Patients with Allergic
Conjunctivitis
Hanna Zygmunt1, Paweł
Lipowski2, Marta Chełmińska3
1 Oddział Okulistyczny 7. Szpitala Marynarki Wojennej
w Gdańsku
Ordynator: lek. med. Andrzej Król
2 Katedra i Klinika Chorób Oczu Akademii Medycznej w
Gdańsku
Kierownik: prof. dr hab. n. med. Krystyna Raczyńska
3 Klinika Alergologii Katedry Pneumonologii i
Alergologii Akademii Medycznej w Gdańsku
Kierownik: dr hab. n. med. Ewa Jassem |
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| Summary: |
Aim: Eosinophil cationic
protein indicates the allergic reaction intensity, as
well as in serum and tears. The aim of this study was to
estimate alteration in ECP concentration in tears,
before and after treatment with ketotifen ophthalmic
solution.
Methods: tears were collected from 18 patients with
seasonal allergic conjunctivitis or perennial allergic
conjunctivitis. The investigation of the patients
included history of atopy. None of the patients received
any systematical or topical medicines. Clinical signs of
ocular allergy were evaluated using Abelson scale.
Shirmer’s tests, tear break-up time and skin prick tests
also were carried out. Tears were collected from the
lateral canthus of one eye in each subject in 50 µl
before and after 20 days of treatment. The samples were
kept at –20°C until they had been analyzed. Eosinophil
cationic protein amount in tears was analyzed with
enzyme–immunoassay for ECP (Pharmacia CAP 100E System
UniCAP ECP).
Results: patient’s ocular allergy clinical symptoms
intensity correlated with ECP tear concentration
alteration. After treatment, signs of allergic
conjunctival reaction subsided. We noticed increased
congestion intensity, itching and tearing only in one
patient. Four of the patients did not show up for the
follow–up visit after treatment.
Conclusions: all patients with allergic conjunctivitis (except
one subject) showed reduced symptoms of allergic
reaction after treatment with ketotifen ophthalmic
solution. Symptoms and the tear ECP amount correlated
significantly in all examined patients. Due to the small
number of samples (high costs), those studies required
further investigation. |
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| Key words: |
allergic conjunctivitis,
Eosinophils, Tear ECP, Ketotifen ophthalmic solution. |
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