|
NR. 3(I)/2007
|
|
|
|
|
|
|
|
|
Czynnik wzrostu
śródbłonka naczyń w patogenezie postaci wysiękowej zwyrodnienia
plamki związanego z wiekiem
Vascular Endothelial Growth Factor and Pathogenesis of Exudative
Age-Related Macular Degeneration
Halina Wykrota, Krzysztof
Trzciąkowski
Samodzielny Publiczny Szpital Kliniczny Nr 5
Śląskiego Uniwersytetu Medycznego w Katowicach
Dyrektor: prof. dr hab. n. med. Ariadna Gierek-Łapińska |
|
|
|
|
|
|
|
| Summary: |
Despite intensive and
large scientific works on neovascular age-related
macular degeneration (AMD) pathogenesis that have been
made in last years accurate explanation of its origin
remains unknown. We have learned anyway, that on the
very early stage of the disease pathological
angiogenesis is one of the major importances.
New pathologic vessels grow from the fenestrated
choriocapillaries and by crossing the Bruch’s membrane
and retinal pigment epithelium (RPE) harm the
neuroretina. The new immature and leaky vessels cause
oedema and bleeding and finally organize into
fibrovascular tissue. These symptoms are responsible for
severe vision loss that can occur in a very short time
from the disease beginning. Although primary impulse for
neovascularization is unknown, the whole process is
similar to angiogenesis that plays an important role in
physiological conditions as well. Vascular endothelial
growth factor is considered to be a key element of
angiogenesis cascade. Development of anti-VEGF compounds
allows implementing new treatment modalities of
neovascular age-related macular degeneration. In this
review we describe VEGF’s features and the role that it
plays in pathological ocular neovascularization. |
| |
|
| Key words: |
vascular endothelial
growth factor, angiogenesis, age-related macular
degeneration, choroidal neovascularization. |
|
|
|
|
|
|
|
|
