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NR. 3(I)/2007
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Terapia
fotodynamiczna (PDT) w leczeniu wysiękowej postaci zwyrodnienia
plamki związanego z wiekiem – obserwacje 5-letnie
Photodynamic Therapy (PDT) in the Exudative Form of Age-Related
Macular Degeneration Treatment – 5 Years Observation
Sława Kwiecień, Jerzy Szaflik
Katedra i Klinika Okulistyki II Wydziału Lekarskiego Akademii
Medycznej w Warszawie
Samodzielny Publiczny Kliniczny Szpital Okulistyczny w Warszawie
Kierownik: prof. dr hab. n. med. Jerzy Szaflik |
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| Summary: |
Photodynamic therapy has
been shown to be effective in helping to prevent further
vision loss in patients affected by exudative (wet)
macular degeneration. Photodynamic therapy does not use
heat, so it does not cause damage, and procedure can be
repeated as many times as necessary based on patients
ocular condition. BPD-MA medicine is injected
intravenously. Medicine is then picked up by blood
lipoproteins, which are taken up specifically by the
abnormal blood vessels in the retina. Next a beam of red
laser light is aimed into the eye, activates the drug,
which results in the singlet oxygen and free radicals
formation that can lead to vascular endothelial cellular
damage, platelet aggregation, thrombosis, and CNV
occlusion within treated area. The results of a
multi-center phase IIIb randomized placebo-controlled
study confirmed the benefits of therapy in the treatment
of choroidal neovascularization. |
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| Key words: |
choroidal
neovascularization, phototoxic reaction, treatment of
age-related macular degeneration, photodynamic therapy. |
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