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NR. 1/2008
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Patogenetyczne i
kliniczne aspekty naczyniowej teorii jaskry
Pathogenetic and Clinical Aspects of the Vascular Glaucoma
Theory
Joanna Wierzbowska, Andrzej
Stankiewicz
Klinika Okulistyczna Centralnego Szpitala Klinicznego
Ministerstwa Obrony Narodowej
Wojskowego Instytutu Medycznego w Warszawie
Kierownik: prof. dr hab. n. med. Andrzej Stankiewicz |
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| Summary: |
In a review the present
pathogenetic concept of glaucomatous optic neuropathy
and four elements of this process were presented: neural
tissue loss, glia activation, tissue remodelling and
change of blood flow were analyzed. Role of risk factors,
especially vascular ones, disturbed autoregulation,
mechanism of reperfusion injury and oxidative stress
were emphasized. Finally, present and future therapeutic
approaches, regarding vascular aspects of glaucoma
pathogenesis were described. |
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| Key words: |
glaucomatous optic
neuropathy, risk factors, ocular blood flow, oxidative
stress, reperfusion damage, vascular disregulation. |
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