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NR. 1/2008
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Ekspresja receptora
Fas w aksonach nerwu wzrokowego
Fas Receptor Expression in the Optic Nerve Axons
Renata Zalewska1,
Katarzyna Komaszyło1, Ewa Proniewska-Skrętek1,
Joanna Reszeć2, Zofia Mariak1
1Klinika Okulistyki Akademii Medycznej w Białymstoku
Kierownik: prof. dr hab. n. med. Zofia Mariak
2Zakład Patomorfologii Akademii Medycznej w
Białymstoku
Kierownik: prof. dr hab. n. med. Lech Zimnoch |
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| Summary: |
Apoptosis is one of the
main processes underlying neurodegenerative diseases and
can contribute to the retinal ganglion cells loss in
glaucoma. We already know several modulators (Fas,
Bcl-2, Bax, Bcl-xl) which can regulate cell apoptosis in
the optic nerve head. The aim of our study was
evaluation of Fas immunoexpression in optic nerve axons
in the eyeballs which were enucleated due to the
absolute glaucoma and severe injury. We examined a
series of 17 eyeballs which were enucleated due to
absolute glaucoma with ophthalmalgia and series of 8
eyeballs (control group) which were enucleated because
of extensive trauma in 1994-2005 in the Department of
Ophthalmology Medical University of Białystok. The
samples were immunostained with human antibody for Fas.
Immunoexpession was evaluated in retrolaminar region of
the optic nerve head. In our study, Fas immunoexpression
was stronger in the axons with absolute glaucoma than in
trauma group (p=0.0084). The result of our study might
suggest that Fas plays a significant proapoptotic role
in optic nerve axons in the stage of absolute glaucoma. |
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| Key words: |
optic nerve axons, Fas,
apoptosis, glaucoma. |
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