|
NR. 4(II)/2008
|
|
|
|
|
|
|
|
|
Skuteczność i
bezpieczeństwo ofloksacyny w leczeniu bakteryjnych zapaleń oka –
przegląd piśmiennictwa
Review of the Efficacy and Safety of Ofloxacin for the Treatment
of Ocular Infections
Charles Slonim1, Jacek P. Szaflik2
1 Department of Ophthalmology, University of South
Florida College of Medicine, Tampa, FL (USA)
2 Katedra i Klinika Okulistyki II Wydziału
Lekarskiego Warszawskiego Uniwersytetu Medycznego
Samodzielny Publiczny Kliniczny Szpital Okulistyczny w Warszawie
Kierownik: prof. dr hab. n. med. Jerzy Szaflik |
|
|
|
|
|
|
|
| Summary: |
Common external bacterial
infections of the eye, including blepharitis,
conjunctivitis, and keratitis (e.g., corneal ulcers) can
be successfully treated with administration of a topical
ophthalmic antibiotic effective against gram-positive
and gram-negative pathogens. The introduction of topical
ophthalmic fluoroquinolone antibiotics provided the
first class of antibiotics that are highly effective
against Pseudomonas and Staphylococcus species without
the need of fortification for the treatment of bacterial
keratitis. Topical ophthalmic fluoroquinolone
antibiotics are safer than fortified antibiotics.
Ofloxacin 0.3% ophthalmic solution has demonstrated
efficacy and safety in the treatment of bacterial
conjunctivitis and bacterial keratitis. It penetrates
the cornea and is effective when used as prophylaxis for
cataract surgery. Despite some reports of in vitro
resistance, most common ocular pathogens remain
clinically susceptible to ofloxacin 0,3%. Topical
administration of ofloxacin 0,3% is equally well
tolerated as lubricant eye drops. It rarely causes
systemic adverse effects, and it is rarely is associated
with adverse effects on visual acuity, ophthalmoscopic
findings, or lens pathology. |
| Key words: |
ofloxacin, ocular
bacterial infections, efficacy, safety, fluoroquinolones. |
| Słowa kluczowe: |
ofloksacyna, bakteryjne
zapalenia oka, skuteczność, bezpieczeństwo. |
|
|
|
|
|
|
|
|
