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NR. 3(I)/2009
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Endogenne inhibitory
angiogenezy a neowaskularyzacja oczna
Endogenous Angiogenic Inhibitors and Ocular Neovascularization
Iwona Jaworowska-Cieślińska1,
Grażyna Malukiewicz1, Ewa Żekanowska2
1 Katedra i Klinika Chorób Oczu Uniwersytetu im.
Mikołaja Kopernika w Toruniu
Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy
Kierownik: prof. dr hab. n. med. Józef Kałużny
2 Katedra Patofizjologii, Zakład Zaburzeń Hemostazy
Uniwersytetu im. Mikołaja Kopernika w Toruniu
Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy
Kierownik: dr hab. Danuta Rość, prof. UMK |
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| Summary: |
Angiogenesis is a complex
process depending on many stimulating and inhibiting
factors. In the healthy human organism angiogenesis
inhibiting factors such as: thrombospondin, endostatin,
angiostatin, metalloproteinases inhibitors, platelet
factor 4 and others. When organism is affected by a
disease, direct and indirect factors stimulating
angiogenesis dominate. The most important are as follows:
VEGF, bFGF, metalloproteinases, angopoietin, integrins,
nitric acid. The role of many mediators in angiogenesis
has not been fully determined yet. Hence further
research work is required to determine influence of
these factors. |
| Key words: |
angiogenesis, endogenous
inhibitors, ocular neovascularization. |
| Słowa kluczowe: |
angiogeneza, inhibitory
endogenne, neowaskularyzacja oczna. |
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