NR 3-4/2003
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Zastosowanie zieleni indocyjaninowej w
leczeniu fotodynamicznym czerniaka naczyniówki - doniesienie wstępne
Photodynamic therapy with indocyanine green for
choroidal melanoma - a preliminary report
Agnieszka Kubicka-Trz±ska, Maria Starzycka, Bożena
Romanowska-Dixon, Krzysztof Morawski
Z Katedry i Kliniki Okulistyki Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie
Kierownik: prof. dr hab. n. med. Maria Starzycka |
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| Summary: |
Purpose: to evaluate the usefulness of
indocyanine green (ICG) in the photodynamic therapy (iPDT) of choroidal melanoma.
Material and methods: thirty eight patients with choroidal melanoma were
treated with iPDT. Tumor thickness ranged from 2.6 to 4.1 mm in ultrasonography. Before
iPDT Ruthenium-106 plaques were used in 18 cases, in 6 cases with additional
transpupillary thermotherapy ("sandwich method"), and Iodine-125 plaques in 3
cases. In 11 eyes the iPDT was the only performed treatment. Therapy was performed with
810 nm diode laser after intravenous injection of 25 mg solution of indocyanine green. Six
months after iPDT ophthalmological examination was performed with ultrasonography and ICGA
images evaluation.
Results: The baseline ICG study showed pathological intrinsic vasculature
in all examined cases. Six months after iPDT changes in microcurculation, as well as
significant decrease of tumors thickness in ultrasonography (mean 38%), were detected in
all cases. Complete regression of intrinsic vessels was demonstrated by ICGA in 26 cases,
and partial regression of pathological vascularization was found in 12 patients.
Conclusions: Our preliminary study suggests, that ICG mediated iPDT can
be a new and promising way, to treat choroidal melanoma. |
| Słowa kluczowe: |
leczenie fotodynamiczne, zieleń indocyjaninowa, czerniak
naczyniówki. |
| Key words: |
photodynamic therapy, indocyanine green, choroidal melanoma. |
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