NR 3-4/2003
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Zmiany w soczewce i siatkówce a parametry
gospodarki lipidowej i poziom hemoglobiny glikozylowanej u młodych pacjentów chorych na
cukrzycę
The lens and retina changes related to the lipid
parameters and glycosylated hemoglobin in blood among the young patients
Elżbieta Pieńkowska-Machoy, Danuta Karczewicz, Barbara
Torbus-Lisiecka1, Kornel Chełstowski1
Z Katedry Okulistyki z Kliniką i Zakładem Patofizjologii Narządu Wzroku
Kierownik: prof. dr hab. n. med. Danuta Karczewicz
1Z Katedry Biochemii Klinicznej i Diagnostyki Laboratoryjnej
Pomorskiej Akademii Medycznej w Szczecinie
Kierownik: prof. dr hab. Marek Naruszewicz |
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| Summary: |
Purpose: The aim of the work was, to find
out the relations between the lipid profile and glycosylated hemoglobin in blood and eye
changes in the diabetic young people.
Material and methods: There were 39 patients (19 women and 20 men), aged
14-27 years (mean 19,5), treated for diabetes during the period 6 - 23 years (mean 9,6).
The ophthalmological examinations have included anterior segment and lens, as well as the
fundus of the eye . There also have been made the blood serum examinations of cholesterol
(CHC), LDL-CHC, HDL-CHC, trigliceride (TG), apolipoproteins B (ApoB) and glycosylated
hemoglobin (HbA1c).
Results: Basing on these examinations it has been stated that:
1. the lens changes were observed in the patients of increased LDL-CHC level and ApoB, who
suffered from diabetes shorter than 10 years, while in the patients suffering longer, lens
changes correlate with the high level of HbA1c;
2. the eye fundus changes correlated substantially in the patients with the high levels of
HbA1c, TG, HDL-CH (negatively), LDL-CH and ApoB, suffering less than 10 years;
in the patients suffering longer, correlation was also with the increased level of HbA1c,
CHC and LDL-CHC.
3. The increased levels of lipids were noted in the patients with the high level of HbA1c.
Conclusions: The stated data have indicated, that the eye changes are
caused by disturbances of lipid parameters, but besides of the glycaemia disorders. The
diabetic duration does not matter for the lipid profile and HbA1c level, but it
is important for the occurrence of eye fundus changes. The HbA1c essentially
influences on the occurrence of eye fundus changes, but in the longer suffering patients,
also on the lens changes. The high HbA1c level shifts the lipid profile towards
atherogenic factors. It is purposeful, to decrease its level below 7%, which is accepted
as good diabetes control. |
| Słowa kluczowe: |
cukrzyca, młodzież, zmiany oczne, lipidy, HbA1c. |
| Key words: |
diabetes mellitus, young people, eye changes, lipids, HbA1c. |
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