NR 6/2003
|
|
|
|
|
|
|
|
|
Neuroendokrynne nowotwory narządu wzroku -
rak z komórek Merkela
Neuroendocrine tumors of visual system - Merkel cell
carcinoma
Heinrich Holak3, Ulrich Weber1, Nikolai Holak1,
Konrad Donhuijsen2
1Z Kliniki Okulistycznej Kliniki Miejskiej, Braunschweig
Kierownik: prof. dr Ulrich Weber
2Z Instytutu Patologii Kliniki Miejskiej, Braunschweig
Kierownik: prof. dr Konrad Donhuijsen
3Z Okulistyki w Centrum Lekarskim im. R. Virchowa, Salzgitter
Kierownik: dr Heinrich Holak |
|
|
| Summary: |
Purpose: To describe cases of Merkel cell
carcinoma. Belonging to the APUD - system tumors, the highly malignant Merkel cell
carcinoma affects in 10% the ocular adnexes, 50-60% of the patients develop a metastasis
to the lymph nodes, and the five year surival rate is only 38%. 30% of the tumors recur
after one year.
Material and methods: In the last eight years the Merkel cell carcinoma
was diagnosed in four patients and was treated by wide resection, radiotherapy and
cytostatic drugs. Histological and immunohistological examination was performed.
Results: In three cases the carcinoma was diagnosed in the upper lid and
in one case in the eyebrow. Two patients could not be cured. Characteristic is clinical
uniform appearance of the tumor as painless, reddish nodule with smooth surface,
telangiectatic blood vessels, fast growing and fast leading to metastasis. Furthermore,
the histological characteristics of the tumor were found as well as NSE, S100 proteins and
neuroendocrine granula, which allow to classify to the APUD - system and to distinguish
from the more benign tumors.
Conclusions: As neuroendocrine tumor the Merkel cell carcinoma represents
a high malignant tumor in ophthalmology. The certain diagnosis is only made by
histological and immunohistological examination. A full - thickness resection followed by
radiation, should be performed as soon as possible. |
| Słowa kluczowe: |
neuroendokrynne nowotwory, rak z komórek Merkela,
immunohistopatologia, leczenie - wycięcie, naświetlanie. |
| Key words: |
neuroendocrine tumors, Merkel cell carcinoma,
immunohistology, resection, radiation. |
|
|
|
|
|
|
