NR 6/2003
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Nowe metody leczenia autoimmunologicznych
zapalnych schorzeń narządu wzroku
New methods of therapy for ocular inflammatory
autoimmune diseases
Agnieszka Kubicka-Trząska1, Anetta Undas2
1Z Katedry i Kliniki Okulistyki Collegium Medicum Uniwersytetu Jagiellońskiego
w Krakowie
Kierownik: prof. dr hab. n. med. Maria Starzycka
2Z II Katedry Chorób Wewnętrznych Collegium Medicum Uniwersytetu Jagiellońskiego
w Krakowie
Kierownik: prof. dr hab. n. med. Andrzej Szczeklik |
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| Summary: |
The authors review the current literature, regarding the
efficacy and safety of new methods of therapy for ocular inflammatory autoimmune diseases:
scleritis, pemphigoid and uveitis. Immunomodulation therapy is increasingly being used in
various ocular inflammatory diseases, to avoid the effects of long-term steroid and
immunosuppressive therapy and to induce remission in chronic disease. This therapy seems
to be effective specially in treating resistant disease with relative safety. New
approaches to therapy of intraocular inflammatory diseases will emphasize less
immunosuppressive drugs and modification of the immune system with anti-MHC II,
anti-adhesion molecules, anti- cytokines monoclonal antibodies, therapy with cytokines
antagonists, intravenous immunoglobulin therapy, INF alpha therapy, antigen specific
tolerancing therapy and gene therapy. Advances in the understanding of pathogenesis and in
diagnostic techniques in various ocular inflammatory entities, will serve as a driving
force for these new methods of treatment. |
| Słowa kluczowe: |
cytokiny, adhezyny, monoklonalne przeciwciała, zapalenie
twardówki, pemfigoid oczny, zapalenie błony naczyniowej. |
| Key words: |
cytokines, adhesion molecules, monoclonal antibodies,
scleritis, ocular pemphigoid, uveitis. |
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