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NR 1-2/2004
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Wpływ rilmenidyny na
ciśnienie wewnątrzgałkowe u królików.
Interakcja z efaroksanem i rauwolscyną
The influence of rilmenidine
on intraocular pressure
in rabbits. Interaction with efaroxan and rauwolscine
Marta Misiuk-Hojło1, Marek
Szaliński1, Anna Merwid-Ląd2,
Małgorzata Trocha2, Małgorzata Pieśniewska2
1 Z Katedry i Kliniki Okulistyki Akademii Medycznej
we Wrocławiu
Kierownik: prof. dr hab. n. med. Maria Hanna Niżankowska
2 Z Katedry i Zakładu Farmakologii Akademii Medycznej
we Wrocławiu
Kierownik: dr hab. n. med. Adam Szeląg |
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| Summary: |
Purpose: Glaucoma
is the main cause of blindness in the developed
countries. Its progress can be diminished by decreasing
intraocular pressure (IOP) using pharmacological or
surgical treatment. Antiglaucoma agents, a2 –
adrenergic's receptor agonists have been known for
several years as IOP lowering. Due to the fact that the
majority of them turned out to be imidazoline receptor
agonists, it is worth checking if selective imidazoline
receptor (I1) agonists alter IOP. Preliminary animal
experiments show that they lower IOP. In our study we
examined the influence of rilmenidine, a potent I1
receptor agonist, on IOP in rabbits. Furthermore, we
tried to find out whether I1 and a2 receptor antagonists
(efaroxan and rauwolscine) counteract the
pharmacological effect of rilmenidine.
Material and methods: The study was conducted on
adult male White New Zealand rabbits. All the substances
were administered topically, and IOP was measured by
applanation tonometry after topical anaesthesia before
and 1, 3 and 5 hours after drug instillation.
Results: Rilmenidine showed the lowering effect
on IOP at the concentration of 0,4%. Efaroxan and
rauwolscine partly inhibited rilmenidine effect.
Conclusions: Rilmenidine is a potential
antiglaucoma agent, though further studies are necessary. |
| Słowa kluczowe: |
ciśnienie wewnątrzgałkowe,
rilmenidyna, efaroksan, rauwolscyna, jaskra, badania na
zwierzętach. |
| Key words: |
Intraocular pressure,
rilmenidine, efaroxan, rauwolscine, glaucoma, animal
study. |
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