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NR 1-2/2004
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Neowaskularyzacja w
tkankach oka: mechanizmy i rola czynników pro- i
antyangiogennych
Neovascularization in ocular
tissues: mechanisms and role of proangiogenic and antiangiogenic
factors
Jerzy Z. Nowak, Anna Wiktorowska-Owczarek
Z Zakładu Farmakologii Uniwersytetu Medycznego w Łodzi
Kierownik: prof. dr hab. n. med. Jerzy Z. Nowak |
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| Summary: |
Blood vessel growth and
stability are under precise control of an array of pro-
and anti-angiogenic factors. Under physiological
conditions, actions of particular regulatory factors, as
well as their mutual interactions are harmonized and
balanced. Disruption of the balance between these pro-
and anti-angiogenic factors is characteristic of many
vascular diseases, including those occurring within the
eye. Functional dominancy of proangiogenic factors (e.
g., vascular endothelial growth factor, VEGF) over
antiangiogenic ones (e. g., pigment epithelium-derived
growth factor, PEDF), which may occur under ischemic
conditions, may initiate the process of retinal or
choroidal neovascularization, representing a major
threat to the eyesight. This article presents and
discusses current ideas concerning molecular and
cellular processes underlying aberrant growth on new
blood vessels in ocular tissues, in relation to
microvascular ocular complications associated mainly
(but not only), with diabetes mellitus, age-related
macular degeneration (AMD), and retinopathy of
prematurity (ROP). This review also surveys latest
achievements in the field of clinically more effective
future therapeutic strategies, including gene therapy
applicable to the neovascular eye diseases. |
| Słowa kluczowe: |
neoangiogeneza
fizjologiczna i patologiczna, VEGF, MMP, PEDF, receptory
integrynowe, ROP, DR, AMD. |
| Key words: |
neoangiogenesis
physiological and pathological, VEGF, MMP, PEDF,
integrins' receptors, ROP, DR, AMD. |
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