|
NR 1-2/2004
SUPLEMENT
|
|
|
|
|
|
|
|
|
Poziom tlenku azotu
w cieczy wodnistej u pacjentów z jaskrą
Nitric oxide level in
aqueous humor in patients with glaucoma
Ewa Kosior-Jarecka1, Marek
Gerkowicz2, Małgorzata Latalska2, Maria
Kozioł-Montewka2, Agnieszka Szczepanik1
1Z Katedry i Zakładu Mikrobiologii Lekarskiej
Akademii Medycznej im. prof. Feliksa Skubiszewskiego w Lublinie
Kierownik: prof. dr hab. n. med. Maria Kozioł-Montewka
2Z II Kliniki Okulistyki Akademii Medycznej im. prof.
Feliksa Skubiszewskiego w Lublinie
Kierownik: dr hab. n. med. Marek Gerkowicz |
|
|
| Summary: |
Purpose: There is
increasing evidence suggesting, that nitric oxide may be
implicated in the pathogenesis of glaucoma. The aim of
the study was to evaluate nitric oxide level in aqueous
humor of glaucoma patients.
Material and methods: The examined group was
constituted by 26 persons (13 women and 13 men), aged
60-86 (mean age 70) suffering from glaucoma. In 14
patients glaucoma was classified as POAG and in 12 as
PACG. All patients have undergone trabeculectomia.
The 14 patients was operated because of age-related
cataract (8 women and 6 men), aged 47-82 (mean age 65),
constituted a control group. All patients agreed to
samples collection.
Level of nitric oxide in anterior chamber fluid was
assessed using commercial kits based on Griess reaction
(R&D) according to manufacturer's instruction.
Statistical analysis was performed using U Mann-Whitney
test.
Results: The mean level of nitric oxide in
aqueous humor was not significantly different between
glaucoma and cataract group (p=0,535). The level of NO
in humor aqueous was statistically significantly lower
in patients with primary open angle glaucoma than in
patients with primary angle closure (p=0,022), and than
in control group (p=0,053). No statistically significant
differences in the level of nitric oxide in humor
aqueous between PACG and cataract patients were observed
(p=0,365). |
| Słowa kluczowe: |
jaskra, tlenek azotu,
ciecz wodnista. |
| Key words: |
glaucoma, nitric oxide,
aqueous humor. |
|
|
|
|
|
|
