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NR 1-2/2004
SUPLEMENT
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Porównanie
skuteczności terapii skojarzonej 0,5% timololem i 2%
dorzolamidem oraz 0,5% timololem i 2% pilokarpiną w leczeniu
jaskry pierwotnej otwartego kąta i nadciśnienia ocznego
Timolol 0,5%/ dorzolamide 2%
fixed combination versus timolol 0,5%/ pilocarpine 2% fixed
combination in primary open-angle glaucoma or ocular
hypertensive patients
Jakub J. Kałużny1, Jerzy
Szaflik2, Krystyna Czechowicz-Janicka3,
Józef Kałużny1, Alicja Orzałkiewicz1, Anna
Zaleska-Żmijewska2, Małgorzata Krajewska3,
Jeanette A. Stewart4, Jessica N. Leech4,
Wiliam C. Stewart4,5
1Z Kliniki Okulistyki Akademii Medycznej im. Ludwika
Rydygiera w Bydgoszczy
Kierownik: prof. dr hab. n. med. Józef Kałużny
2Z Samodzielnego Publicznego Klinicznego Szpitala
Okulistycznego w Warszawie
Kierownik: prof. dr hab. n. med. Jerzy Szaflik
3Z Centrum Medycznego Kształcenia Podyplomowego w
Warszawie
Kierownik: prof. dr hab. n. med. Krystyna Czechowicz-Janicka
4Pharmaceutical Research Network, Limited Liability
Company, Charleston, South Carolina, USA
Kierownik: Jeanette A. Stewart
5Department of Ophthalmology, University of South
Carolina, Columbia, South Carolina, USA
Kierownik: Wiliam C. Stewart |
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| Summary: |
Purpose: To
establish the efficacy and safety of timolol 0,5% /
dorzolamide 2% fixed combination versus timolol 0,5% /
pilocarpine 2% fixed combination, each given twice daily,
in primary open-angle glaucoma and ocular hypertensive
patients.
Material and methods: In this prospective,
multicentred, double-masked trial, 37 patients were
treated twice daily with timolol for 4 weeks. Then, they
were randomized to one of the treatment medications for
6 weeks, after which they were treated with timolol
again for 2 weeks before placed on the opposite
treatment medication for 6 weeks.
Results: A total of 36 patients completed the
trial. The mean baseline intraocular pressure (IOP) was
22,3± 3,7 mmHg. Following 6 weeks of treatment, the mean
decrease of IOP was 18,0± 2,2 mmHg for timolol /
dorzolamide combination and 17,4± 2,0 for timolol /
pilocarpine combination. The mean diurnal curve IOP was
18,1± 2,2 mmHg for timolol / dorzolamide group and 16,7
± 1,9 mmHg for timolol / pilocarpine group. These
differences were statistically significant.
Statistically more patients reported ocular pain and
diminished vision during use of the timolol /
pilocarpine combination.
Conclusions: This study suggest that timolol 0,5%
/ pilocarpine 2% fixed combination can provide at least
similar efficacious reduction in IOP as timolol 0,5 % /
dorzolamide 2% fixed combination in patients with
primary open-angle glaucoma and ocular hypertension.
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| Słowa kluczowe: |
jaskra otwartego kąta,
timolol, dorzolamid, pilokarpina |
| Key words: |
open angle glaucoma,
timolol, dorzolamide, pilokarpine |
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