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NR 3/2004
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Teoretyczne i
kliniczne aspekty zastosowania prostaglandyn w leczeniu jaskry
Theoretical and clinical
aspects of prostaglandins application in glaucoma therapy
Joanna Wierzbowska, Andrzej Stankiewicz
Z Kliniki Okulistycznej Wojskowego Instytutu Medycznego w
Warszawie
Kierownik: prof. dr hab. n. med. Andrzej Stankiewicz |
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| Summary: |
In the first part of the
article the main information and recent research on the
uveoscleral outflow pathway, including its morphology
and physiology were presented. The structure of
extracellular matrix of ciliary muscle and the changes
of it, that are induced by prostaglandins, resulting in
decreasing intraocular pressure were emphasized. In the
second part biochemical characteristics of prostaglandin
analogues, using nowadays were presented. Their efficacy
in reducing intraocular pressure and safety profile were
described. |
| Słowa kluczowe: |
jaskra, odpływ
naczyniówkowo-twardówkowy, macierz zewnątrzkomórkowa
mięśnia rzęskowego, metaloproteinazy macierzy
zewnątrzkomórkowej, analogi prostaglandyn. |
| Key words: |
glaucoma, uveoscleral
outflow, extracellular matrix of ciliary muscle, matrix
metalloproteinases, prostaglandins analogues. |
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