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NR 3/2004
SUPLEMENT
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Peroksydacja lipidów
u chorych z zaćm± starcz±
Peroxidation of lipids in
patients with senile cataract
Justyna Kłos-Rola, Zbigniew Zagórski
Z Katedry i I Kliniki Okulistyki Akademii Medycznej w Lublinie
Kierownik: prof. dr hab. n. med. Zbigniew Zagórski |
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| Summary: |
Purpose: The aim of the
study was to elucidate a potential relationship between
systemic and intraocular (aqueous humor and lens) levels
of lipid peroxidation products (LPO) during development
of senile cataract.
Materials and methods: Population examined included 59
females and 44 males (average age 67,1 ± 10,78), who
underwent surgical cataract extraction. They were
divided into 3 groups based on cataract stage.
Conjugated diens (CD) and malonyl dialdehyde (MDA)
levels in lens nuclei, aqueous humor and blood sera,
were assessed.
Results: Our results showed significant increase of CD
and MDA levels in lens nuclei and aqueous humor with
clinical advancement of cataract accompanied by
increases of serum CD and MDA levels. Significant,
positive correlations between analyzed parameters were
noticed.
Conclusions: This indicates that systemic lipid
peroxidation may affect local advancement of the disease
within the lens through the influence on intraocular
levels of LPO. |
| Słowa kluczowe: |
zaćma starcza,
peroksydacja lipidów, soczewka, płyn komorowy, surowica
krwi. |
| Key words: |
senile cataract, lipid
peroxidation, lens, aqueous humor, blood serum. |
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