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NR 3/2004
SUPLEMENT
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Poziom przeciwciał
antyfosfolipidowych w surowicy i cieczy wodnistej pacjentów z
jaskrą
Levels of antiphospholipid
antibodies in the serum and aqueous humor in glaucoma patients
Małgorzata Latalska1, Marek
Gerkowicz1, Małgorzata Pietraś-Trzpiel1,
Maria Kozioł-Montewka2, Ewa Kosior-Jarecka2
1Z II Kliniki Okulistyki Akademii Medycznej im. prof.
Feliksa Skubiszewskiego w Lublinie
Kierownik: dr hab. n. med. Marek Gerkowicz
2Z Katedry i Zakładu Mikrobiologii Lekarskiej
Akademii Medycznej im. prof. Feliksa Skubiszewskiego w Lublinie
Kierownik: prof. dr hab. n. med. Maria Kozioł-Montewka |
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| Summary: |
Purpose: Evaluation
of antiphospholipid antibodies in the serum and aqueous
humor in patients with glaucoma.
Material and methods: 48 persons (38 women and 17
men), aged 30-86 (mean age 70), suffering from glaucoma
was examined. There were 19 with POAG, 18 with PACG and
11 with PEXG. All patients have undergone
trabeculectomia.
The group of 20 operated, because of age-related
cataracta patients (7 men and 13 women), aged 47-82 (mean
age 65) constituted a control group. All patients agreed
to samples collection. In plasma and anterior chamber
fluid the level of antiphospholipids antibodies classes
IgM and IgG were measured, using ELISA method (commercial
kits produced by Euroimmun) according to producent's
instruction. Statistical analysis was performed using U
Mann-Whitney test.
Results: The mean values of antiphospholipids in
both group are put in the table. The significant
differences between glaucoma and no-glaucoma patients
were observed in levels of IgG in serum (p=0,014) and in
levels of IgM antibodies in aqueous humor (p=0,013).
Conclusions: The presence of elevated levels of
antiphospholipid antibodies in aqueous humor and serum
may be a risk factor in progression of glaucomatous
neuropathy. |
| Słowa kluczowe: |
jaskra, przeciwciała
antyfosfolipidowe, zespół antyfosfolipidowy, surowica,
ciecz wodnista. |
| Key words: |
glaucoma, antiphospholipid
antibodies, serum, aqueous humor. |
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