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NR 3/2004
SUPLEMENT
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Aktywność angiogenna
i stężenie VEGF w surowicach chorych na cukrzycę powikłaną
retinopatią prostą
Angiogenic activity and VEGF
level in sera of diabetic patients with non-proliferative
retinopathy
Piotr Skopiński1,2, Barbara
Duda-Król3, Anna Lipińska4, Ewa Sommer5,
Joanna Chorostowska-Wynimko5, Urszula Demkow5,
Jerzy Szaflik1, Ewa Skopińska-Różewska5,
Ewa Struzik1
1Z Katedry i Kliniki Okulistyki II Wydziału
Lekarskiego Akademii Medycznej w Warszawie
Kierownik: prof. dr hab. n. med. Jerzy Szaflik
2Z Zakładu Histologii i Embriologii, Centrum
Biostruktury
Kierownik: prof. dr hab. n. med. Stanisław Moskalewski
3Z III Kliniki Chorób Wewnętrznych II Wydziału
Lekarskiego Akademii Medycznej w Warszawie
Kierownik: prof. dr hab. n. med. Wojciech Łada
4Z Kliniki Chorób Wewnętrznych Oddziału Stomatologii
Akademii Medycznej w Warszawie
Kierownik: prof. dr hab. n. med. Danuta Pfeiffer
5Z Zakładu Diagnostyki Laboratoryjnej i Immunologii
Instytutu Gruźlicy i Chorób Płuc w Warszawie
Kierownik: prof. dr hab. n. med. Ewa Skopińska-Różewska |
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| Summary: |
Diabetic retinopathy is
one of the most common causes of blindness. The majority
of studies concerning this problem were performed in
patients with late stage of disease, demonstrating
proliferative retinopathy, when malformations of retinal
vessels became irreversible (1). Numerous angiogenic
factors related to retinal angiogenesis have been
described. Among them, VEGF is thought to be the major
mediator of proliferative retinopathy (2,3,4). Our
present study was performed on sera collected from
patients with earlier stage of ocular complications,
manifested as background retinopathy. We have believed
that the knowledge of the earliest events leading to
pathological angiogenesis may be valuable for
establishing some prophylactic regimens. Sera of 22
persons with DM1, aged 33-70 years, 37 persons with DM2,
aged 37-79 years, 51 healthy people, aged 22-80 years
(as controls) were studied. Direct serum-induced
cutaneous angiogenesis test in mice (SIA) was applied
(5,6). VEGF concentration in sera was mesured by ELISA
(R & D Systems) test. Angiogenic activity and VEGF
concentration of DM1 patients sera were highly
statistically lower than these parameters in DM2
patients and controls. |
| Słowa kluczowe: |
angiogeneza, retinopatia
nieproliferacyjna, VEGF, cukrzyca typu 1. i typu 2. |
| Key words: |
angiogenesis,
non-proliferative retinopathy, VEGF, diabetes type 1
(DM1) and type 2 (DM2). |
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