|
NR 3/2004
SUPLEMENT
|
|
|
|
|
|
|
|
|
Immunologiczne
aspekty choroby przeszczepu oraz doświadczenia własne ze
stosowania terapii immunosupresyjnej u pacjentów wysokiego
ryzyka
Immunological aspects of
corneal graft rejection and own experience in immunosuppressive
therapy in high risk patients
Anna Kamińska, Jerzy Szaflik, Grażyna
Minkiewicz-Timler, Małgorzata Sybilska, Martyna
Pawluczyk-Dyjecińska, Monika Smolarek
Z Katedry i Kliniki Okulistyki II Wydziału Lekarskiego Akademii
Medycznej w Warszawie
Samodzielny Publiczny Kliniczny Szpital Okulistyczny w Warszawie
Kierownik: prof. dr hab. n. med. Jerzy Szaflik |
|
|
| Summary: |
The aim of the study was
to present factors responsible for immune privilege of
corneal graft, pathogenesis of immunological corneal
graft rejection, and the influence of immunosuppressive
therapy on keeping clarity of corneal graft. We also
present retrospective evaluation of prophylactic
immunosuppressive therapy in high-risk patients and in
cases of graft rejection, in group of patients after
corneal transplantation performed in Department of
Ophthalmology in years 2001-2003. 349 cases of
penetrating keratoplasty, lamellar or penetrating with
limbal transplantation were analyzed. Condition
requiring keratoplasty, surgical procedures, profile of
immunosuppressive therapy, number of recurrences of
corneal graft rejection and changes of visual acuity
were evaluated. Immunosuppressive therapy with oral
corticosteroids and systemic Cyclosporine allow to keep
clarity of corneal graft and useful visual acuity in 60%
cases of high-risk patients. |
| Słowa kluczowe: |
przeszczep rogówki
wysokiego ryzyka, choroba przeszczepu, uprzywilejowanie
immunologiczne, leczenie immunosupresyjne. |
| Key words: |
high risk corneal grafting,
graft rejection, immune privilege, immunosuppressive
therapy. |
|
|
|
|
|
|
