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NR 3/2004
SUPLEMENT
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Zjawiska
immunologiczne prowadzące do patologii filmu łzowego. Czy
cyklosporyna będzie przełomem w leczeniu zespołu Sjögrena?
Doniesienie wstępne
Immunological phenomenons in
the pathology of the tear film. Is cyclosporine the turn point
in the Sjögren’s syndrome treatment? Preliminary report
Agnieszka Kujawa, Radosław Różycki
Z Kliniki Okulistycznej Wojskowego Instytutu Medycznego w
Warszawie
Kierownik: prof. dr hab. n. med. Andrzej Stankiewicz |
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| Summary: |
Purpose: The
purpose of this study is to examine the new way in the
casual treatment, resulting in the normalization of
immunological processes on the ocular surface.
Material and methods: 5 patients (4 women and 1
men with mean age of 55,5 years, range 45 to 59 years)
with Sjögren’s syndrome – type dry eye, were included in
the study. Patients received topically 0,05%
cyclosporine, ophthalmic emulsion twice a day for a 6
months. The severity of patients complaints was
evaluated according to the Dr. Mann Pharma / Bausch &
Lomb’s record.
Results: Schirmer test II values, and lyzamine
green staining scores, were evaluated priori to
treatment and 6 months after the start. At the beginning
of the study (day 0) the Schirmer test II values ranged
from 1 to 5 mm (mean – 2,2 mm). Break-up-time ranged
from 3 to 6 sec (mean – 4,8 sec). In all of 5 cases
lyzamine green staining scores were 9. On month 6th, all
of 5 patients had significant differences, compared to
their baseline measurements in term of above mentioned
parameters. The Schirmer test II values ranged from 8 to
12 mm (mean – 10,3 mm). Break-up-time ranged from 9 to
13 sec (mean – 11,2 sec), lyzamine green staining scores
ranged from 2 to 3 points (mean – 2,7).
Conclusions: 0,05% cyclosporine, ophthalmic
emulsion had a beneficial effect both on the subjective
and objective clinical parameters of dry eye patients.
The final conclusions must be supported by more cases. |
| Słowa kluczowe: |
immunologia, zespół
suchego oka, zespół Sjögrena, cyklosporyna, normalizacja
płynu łzowego. |
| Key words: |
immunology, dry eye
syndrome, Sjögren’s syndrome, tear film’s normalization. |
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