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NR 4-5/2004
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Angiogeneza w
nowotworach barwnikowych b³ony naczyniowej oka. Rola
naczyniowo-¶ródb³onkowego czynnika wzrostu (VEGF)
Tumor angiogensis in uveal
melanoma. Role of vascular endothelial growth factor (VEGF)
Ewa Proniewska-Skrêtek, Zofia Mariak
Z Kliniki Okulistyki Akademii Medycznej w Bia³ymstoku
Kierownik: dr hab. n. med. Zofia Mariak |
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| Summary: |
Neoplastic angiogenesis,
as a process of forming new blood vessels, plays an
important role in progression of cancer tumors and
dissemination of metastases. New vessels can be formed
in cancer tissue due to mutations of certain genes and
under the influence of hypoxia. The process is mediated
by locally delivered specific angiogenetic factors.
Vascular endothelial growth factor (VEGF) plays a
crucial role in stimulation of the vascular endothelial
cells to their proliferation and migration. Intensity of
neoplastic angiogenesis determines the rate and extent
of tumor expansion, thus may heavily influence the
outcome. |
| S³owa kluczowe: |
angiogeneza, czerniak,
b³ona naczyniowa oka. |
| Key words: |
angiogenesis, melanoma,
eye-choroid. |
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