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NR 10-12/2005
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Wzrokowe potencjały
wywołane (FVEP) po prenatalnym stosowaniu soli metali ciężkich –
badania doświadczalne
The visual evoked potentials
(FVEP) after the prenatal exposition for heavy metals –
experimentals studies
Ewa Herba, Dorota Pojda-Wilczek, Stefan
M. Pojda, Agata R. Plech, Katarzyna Makowiecka-Obidzińska,
Andrzej Plech1, Ryszard Szkilnik1, Ryszard
Brus1
Z Katedry i Oddziału Klinicznego Okulistyki Śląskiej Akademii
Medycznej w Katowicach
Szpital Specjalistyczny nr 1 w Bytomiu
Kierownik: prof. dr hab. n. med. Stefan M. Pojda
1Z Katedry i Zakładu Farmakologii w Zabrzu Śląskiej
Akademii Medycznej w Katowicach
Kierownik: prof. dr hab. n. med. Ryszard Brus |
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| Summary: |
Purpose: To find
out, if any and how deep alterations in visual tract are
due to prenatal intoxication by heavy metals such as:
cadmium (Cd), lead (Pb), mercury (Hg) and manganese
(Mn). The measure of these alterations were the changes
in flash visual evoked potentials after prenatal
intoxication.
Material and methods: The experiments were
carried out on 55 white newborns Wistar rats, which were
divided into 5 groups: control group (14 rats), Cd group
(12), Pb ( 6), Hg ( 14) and Mn ( 9). The method of the
FVEP study was described by Pojda et al. (1).
Results: The latencies of the peaks N1 and P1
were prolonged in the Mn group till 113-118% (p< 0.05).
Slight prolongation of N1 latencies about 1% in Cd and
Hg groups and of 4% in Pb group were not statistically
significant. The differences of P1 latencies were not
statistically significant in these groups, compared to
the control group. The amplitude of N1 wave decreased in
Cd group about 63% and in Mn group of 32% compared to
the control (p<0.05). In Hg intoxicated group the N1
amplitude decreased to 56% ( p< 0.01). The amplitude of
P1 decreased in all intoxicated groups ( Hg of 56%, Cd
55%, Mn 49% ) statistically significant , except the Pb
one, in which even 21% decrease was not significant.
Conclusions: The heavy metals prolonged the
latencies and diminished the amplitudes of flash visual
evoked potentials, so may be, they are not only
neurotoxic but also „ophthalmotoxic” factors. |
| Słowa kluczowe: |
metale neurotoksyczne,
wzrokowe potencjały wywołane, szczury. |
| Key words: |
neurotoxic metals, visual
evoked potentials, rats. |
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