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NR 10-12/2005
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Funkcja narządu
wzroku u dzieci i młodzieży leczonych wigabatryną ze szczególnym
uwzględnieniem spostrzeżeń własnych
The function of eye and
vision system in children and youth treated with vigabatrin –
our own experiences
Dorota Pojda-Wilczek1, Ewa
Emich-Widera2, Ewa Herba1, Stefan M. Pojda1,
Elżbieta Marszał2
1Z Katedry i Oddziału Klinicznego Okulistyki Śląskiej
Akademii Medycznej w Katowicach
Szpital Specjalistyczny nr 1 w Bytomiu.
Kierownik: prof. dr hab. n. med. Stefan M. Pojda
2Z Kliniki Pediatrii i Neurologii Wieku Rozwojowego
Śląskiej Akademii Medycznej w Katowicach
Kierownik: prof. dr hab. n. med. Elżbieta Marszał |
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| Summary: |
Purpose: The aim of
this study is to find the relationship between visual
function changes and vigabatrin treatment continuation
or discontinuation.
Material and methods: 19 patients (11 males, 8
females) from 8 to 20 years old, treated with vigabatrin
because of partial epilepsy, were examined. Best
corrected visual acuity, contrast sensitivity and static
visual field were done. The examinations were repeated
after 1-2 months and after 1-2 years. The longest
follow-up was about three years (one girl). In some
children from this group additional elctrophysiologic
tests (ERG, EOG according to ISCEV standards), were done.
Results: Corrected visual acuity was 5/5 in all
eyes. Contrast sensitivity was normal and it was not
changed in follow-up period. Abnormal visual field was
found in more than half of examined patients. The
improvement of visual field occurred after vigabatrin
discontinuation, but in one patient the improvement
occurred although vigabatrin treatment was continued.
Most of the patients refused control ERG and EOG, but in
first examination decreased or border b-wave amplitude
after „flicker 30Hz” was found.
Conclusions: In some patients treated with
vigabatrin reversible visual field changes occurred.
Multicentre study should be performed, to solve the
problem of relationship between visual field changes,
vigabatrin and other antiepileptic treatment. All tests
in group of epileptic patients are difficult because of
poor cooperation. |
| Słowa kluczowe: |
wigabatryna, pole
widzenia, dzieci. |
| Key words: |
vigabatrin, visual field,
children. |
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