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NR 10-12/2005
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Znaczenie
metabolizmu tlenowego siatkówki w patogenezie zwyrodnienia
plamki związanego z wiekiem
The role of retinal oxygen
metabolism in origin of age-related macular degeneration (AMD)
Michał Nowak, Witold Gnitecki, Piotr
Jurowski
Z Kliniki Okulistyki i Rehabilitacji Wzrokowej Uniwersyteckiego
Szpitala Klinicznego nr 2 im. WAM Uniwersytetu Medycznego w
Łodzi
Kierownik: prof. dr hab. n. med. Roman Goś |
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| Summary: |
Age-related macular
degeneration (AMD) is the leading cause of visual loss
in individuals over 60 years old, in developed countries.
This article provides the latest information about the
role of retinal oxygen metabolism in origin of that
disease. It is considered that reactive oxygen species (ROS),
including free radicals are responsible for apoptotic
cell death and developing of pathological changes in AMD.
Exposure to visible light induces dysfunction of retinal
pigment epithelial cells, accumulation of lipoprotein
aggregates in Bruch’s membrane, formation of drusen, and
final results are damage to photosensitive retina, which
leads to AMD. There are many of antioxidant systems in
retina, which protect tissue from ROS. In this review we
focus on their actions in terms of mechanisms of
preventing oxidative damage and their potential role in
therapy of AMD. There is strong evidence suggesting the
supporting role of the nutritional antioxidant
supplementation and protection from exposure to the
visible light in the prevention and treatment of
age-related macular degeneration. |
| Słowa kluczowe: |
zwyrodnienie plamki
związane z wiekiem, reaktywne formy tlenu,
antyoksydanty. |
| Key words: |
age-related macular
degeneration, reactive oxygen species, antioxidants. |
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