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NR 1-3/2005
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Czynnik von
Willebranda w osoczu chorych ze starczym zwyrodnieniem plamki
Von Willebrand factor in
plasma of patients with age related macular degeneration
Grażyna Malukiewicz-Wiśniewska1,
Danuta Rość2, Bartłomiej Kałużny1, Jakub
J. Kałużny1
1Z Katedry i Kliniki Chorób Oczu Collegium Medicum
Uniwersytetu Mikołaja Kopernika w Bydgoszczy
Kierownik: prof. dr hab. n. med. Jakub Kałużny
2Z Katedry i Zakładu Patofizjologii Collegium Medicum
Uniwersytetu Mikołaja Kopernika w Bydgoszczy
Kierownik: prof. dr hab. n. med. Danuta Rość |
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| Summary: |
Purpose: To
evaluate the plasma level of von Willebrand factor (vWf:
Ag) in patients with age related macular degeneration
and to establish the relation between this factor and
the stage and progresion of the disease.
Material and methods: The group studied comprised
34 patients with age related macular degeneration.
Excluded were patients with diseases and with other
factors which could have changed evaluated parameters.
Patients studied were categorized into 7 groups
according to the stage of disease. The progression of
the disease was evaluated on the base of examination
performed after 6 months' interval. Mean age of the
patients in analysed group was 73,3 (SD=19,5) years. The
control group consisted of 32 healthy persons of similar
age. Statistical analysis were performed with U
Mann-Whitney test and Spearman correlation test.
In both groups blood was sampled from cubital vein. In
blood of patients, von Willebrand levels were measured
by means of ELISA using commercial antibodies (DAKO,
Denmark).
Results: Von Willebrand concentration was
significantly higher in patients with age related
macular degeneration as compared with control group
(p<0.001). Concentration of vWf: Ag correlated
positively with the grade of macular changes and the
progression of the disease.
Conclusions: The data obtained show, that age
related macular degeneration is associated with elevated
plasma levels of von Willebrand factor (a marker of
endothelial injury) and that there is a positive
correlation of it's concentration with both stage and
progression of the disease. |
| Słowa kluczowe: |
starcze zwyrodnienie
plamki, hemostaza, czynnik von Willebranda. |
| Key words: |
age related macular
degeneration, hemostasis, von Willebrand factor. |
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