|
NR 4-6/2005
|
|
|
|
|
|
|
|
|
Ekspresja antygenu
HLA-DR na komórkach nabłonka spojówki u pacjentów z zespołem
suchego oka
HLA-DR antygen expression on
conjunctival epithelial cells in patients with dry eye
Małgorzata Mrugacz, Nella Żywalewska
Z Kliniki Okulistyki Dziecięcej Akademii Medycznej w Białymstoku
Kierownik: prof. dr hab. n. med. Alina Bakunowicz-Łazarczyk |
|
|
| Summary: |
Purpose: The aim of
this study was to investigate the expression of HLA-DR
antigen on conjunctival epithelial cells from patients
with dry eye.
Material and methods: Ophthalmic examination and
dry eye diagnostic tests were performed. Impression
cytology specimens were collected in thirty patients
with dry eye and in thirty people of control group.
Conjunctival epithelial cells were processed for flow
cytometry, by using monoclonal antibodies to HLA-DR.
Results: A significant increase of HLA-DR
expression on epithelial cells was found in patients
with dry eye compared with normal eyes. We also found
positive correlation of increased expression HLA-DR with
ocular complaints and diagnostic tests for dry eye such
as Schirmer test, FBUT and lissamine green staining.
Conclusions: These results confirm the presence
of immunological processes in the pathogenesis of dry
eye syndrome. Increased expression of HLA-DR antygen
positively correlates with the parameters of dry eye
diagnostic tests. HLA-DR measurement might be a useful
method for monitoring inflammatory conjunctival changes
in this disorder. |
| Słowa kluczowe: |
zapalenie, cytometria
przepływowa, cytologia impresyjna, suche oko. |
| Key words: |
inflammation, flow
cytometry, impression cytology, dry eye. |
|
|
|
|
|
|
