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NR 4-6/2005
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Leczenie
zaawansowanych przypadków zespołu suchego oka 0,05% roztworem
cyklosporyny
A 0,05% cyclosporine
treatment of the advanced dry eye syndrome
Agnieszka Kujawa, Radosław Różycki
Z Kliniki Okulistyki Wojskowego Instytutu Medycznego w Warszawie
Kierownik: prof. dr hab. n. med. Andrzej Stankiewicz |
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| Summary: |
Purpose: The
purpose of our study has been to present the results
obtained from the treatment with 0.05% cyclosporine
solution in drops in patients with severe aggravation of
dry eye syndrome manifestations who otherwise did not
suffer from any systemic disease (a three-month
treatment). Another group in whom we used the same
treatment were those who suffered from dry eye syndrome,
which developed in the course of Sjogren’s syndrome, and
graft versus host disease following bone marrow
transplantation (a six-month treatment).
Material and Methods: The study comprised 15 dry
eye syndrome patients (30 eyes), who were divided into
three groups. In Group I were those with severe
aggravation of dry eye syndrome manifestations without
concomitant systemic diseases (3 women), aged 54 to 59
years (mean 57). Group II comprised the patients with
Sjogren’s syndrome (8 women, 1 man), aged 45 to 59 years
(mean 55.5) with graft versus host disease. In Group
III, there were 3 women, aged 52 to 59 years (mean 55)
with graft versus host disease. All the patients were
administered 0.05% cyclosporine topically twice daily.
The Group I patients were given 0.05% cyclosporine
solution for 3 months, those in Groups II and III for 6
months. Subjective complaints were classified according
to the protocol of Dr. Mann Pharma/ Bausch&Lomb.
Results: The effectiveness of the therapy with
0.05% cyclosporine solution was evaluated by the mean
number of points in a five-point Schirmer II test score,
measured before and after the treatment. The Group I
patients (dry eye syndrome without systemic diseases)
were found to have the highest mean number of points –
4. In the Sjogren’s syndrome Group, the mean number of
points was 3.1; and in Group III (graft vs host disease)
the mean value was 2 points. Since the number of
patients was different in particular groups, the
findings have not been compared between themselves.
Conclusions: Using 0.05% cyclosporine solution is
effective in treating patients with dry eye syndrome but
without systemic diseases. In such cases a short,
three-month treatment is sufficient. The 0.05%
cyclosporine treatment is just as effective in patients
with dry eye syndrome and Sjogren’s syndrome or graft
versus host disease. Yet in such cases the treatment has
to be longer and take six months. We observed a mean
increase points in the five-point Schirmer II test score
in all our patients. |
| Słowa kluczowe: |
zespół suchego oka, zespół
Sjögrena, cyklosporyna, normalizacja płynu łzowego. |
| Key words: |
dry eye syndrome,
Sjogren’s Syndrome, cyclosporine, tear films
normalization. |
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