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NR 4-6/2005
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Czy endotelina-1 i
neuropeptyd Y odgrywają rolę w patogenezie neuropatii jaskrowej?
Are endothelin-1 and
neuropeptide Y involved in the pathogenesis of glaucoma?
Barbara Terelak-Borys
Z Kliniki Okulistyki Centrum Medycznego Kształcenia
Podyplomowego SPSK im. prof. W. Orłowskiego w Warszawie
Kierownik: prof. dr hab. n. med. Krystyna Czechowicz-Janicka |
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| Summary: |
Vasospasm in the vessels,
supporting the optic disc, is nowadays considered one of
the possible etiological factors leading to development
of glaucomatous neuropathy. This article describes
physiological regulatory mechanisms of blood circulation
in these vessels, including influence of autonomic
nervous system and blood flow autoregulation; it also
explains why vasospasm may disturb autoregulation.
Special attention is paid to the role of vascular
endothelial mediators, which are responsible for
autoregulation. Observations indicating that vasospasm
may be a risk factor of glaucomatous damage are also
presented. The article describes data concerning
vasospastic effects of two mediators: endothelin-1
(ET-1), released by vascular endothelium, and
neuropeptide Y (NPY), a sympathetic nervous system
neurotransmitter, on the vessels supporting the optic
disc and their possible role in producing blood flow
disturbances in these vessels. Investigation results
indicating that endothelial dysfunction, connected with
increased ET-1 plasma levels and sympathetic nervous
system disorders, may be involved in the pathogenesis of
normal-tension glaucoma, are presented. |
| Słowa kluczowe: |
endotelina-1 (ET-1),
neuropeptyd Y (NPY), skurcz naczyniowy, jaskra pierwotna
otwartego kąta, jaskra z normalnym ciśnieniem
śródgałkowym. |
| Key words: |
endothelin-1 (ET-1),
neuropeptide (NPY), vasospasm, primary open-angle
glaucoma, normal-tension glaucoma. |
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