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NR 4-6/2005
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Rola molekuł
adhezyjnych w rozwoju proliferacyjnej retinopatii cukrzycowej
The role of cellular
adhesion molecule in the development of proliferative diabetic
retinopathy
Joanna Adamiec, Jolanta
Oficjalska-Młyńczak
Z Katedry i Kliniki Okulistyki Akademii Medycznej im. Piastów
¦l±skich we Wrocławiu
Kierownik: prof. dr hab. n. med. Maria Hanna Niżankowska |
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| Summary: |
Development of
proliferative diabetic retinopathy`s pathogenesis is
still unknown. Last years publications seems to show
immuno-inflammatory base of structural and functional
retinal vessels endothelial cells's changes. Chronical
retinal ischemia leads to development of pathological
vessels and formation of fibrovascular tissue at the
vitreoretinale interface. One of the important cause of
the damage is leukocytes activation and adhesion to
vascular endothelium, that is mediated by the specific
adhesion molecules. Increase of soluble cellular
adhesion molecules (CAMs) in serum, vitreous, epiretinal
membranes of patients with PVR seems to confirm its role
in the pathogenesis of this process. This publication
attempts to estimate the CAM's role in progression of
PDR. |
| Słowa kluczowe: |
proliferacyjna retinopatia
cukrzycowa, ¶ródkomórkowa cz±steczka adhezyjna-1,
cz±steczka adhezji komórkowej naczyń, angiogeneza,
leukocyty. |
| Key words: |
proliferative diabetic
retinopathy, intercellular adhesion molecule, vascular
cell adhesion molecule, angiogenesis, leucocyte. |
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