|
NR 7-9/2005
|
|
|
|
|
|
|
|
|
Rola przeciwciał
przeciw pericytom ¶ciany naczyniowej w rozwoju retinopatii
cukrzycowej
The role of anti-pericyte
antibodies in the development of diabetic retinopathy
Joanna Adamiec, Jolanta
Oficjalska-Młyńczak
Z Katedry i Kliniki Okulistyki Akademii Medycznej im. Piastów
¦l±skich we Wrocławiu
Kierownik: prof. dr hab. n. med. Maria Hanna Niżankowska |
|
|
| Summary: |
Diabetic retinopathy is
one of the most common devastating complications of
diabetes. Pericyte loss, microaneurysms and acellular
capilllaries are characteristic for the diabetic retina.
Researches have provided evidence that hyperglycaemia is
one of the main factors driving the onset and
progression of diabetic retinopathy. Although it has
been shown that tight metabolic control has beneficial
effects on the development and progression of this
complication, the increase of blood glucose
concentrations does not account for all the risk for
development and progression to sight threatening
retinopathy. A number of reports suggest that autoimmune
mechanism play a role in diabetic microangiopathy (circulating
antiendothelial cells autoantibodies, antiphospholipid
antibodies, presence of immunoglobulins, lymphocytes and
cytokines in diabetic retinal tissue). Diabetic subjects
were also found to have autoantibodies to microvascular
pericytes in their circulation. These results may
contribute to understanding why retinopathy progresses
in some patients, despite consistent reduction of blood
sugar.
This publication tries to estimate the anti-pericyte
autoantibodies role in progression of diabetic
retinopathy. |
| Słowa kluczowe: |
pericyty, retinopatia
cukrzycowa, autoprzeciwciała, kapilary. |
| Key words: |
pericytes, diabetic
retinopathy, autoantobodies, capillaries. |
|
|
|
|
|
|
