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NR 7-9/2005
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Badanie
autofluorescencji dna oka z zastosowaniem konfokalnego
skaningowego oftalmoskopu laserowego HRA (Heidelberg Retina
Angiograph)
Fundus Autofluorescence
examination using a confocal Scanning Laser Ophthalmoscope HRA
(Heidelberg Retina Angiograph)
Joanna Dolar-Szczasny1, Jerzy
Mackiewicz1, Almut Bindewald2, Frank G.
Holz2, Zbigniew Zagórski1
1Z Katedry i I Kliniki Okulistyki Akademii Medycznej
w Lublinie
Kierownik: prof. dr hab. n. med. Zbigniew Zagórski
2Z Kliniki Okulistycznej Uniwersytetu w Bonn
Kierownik: prof. dr hab. n. med. Frank G. Holz |
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| Summary: |
Purpose: To present
application of a confocal Scanning Laser Ophthalmoscope
(cSLO) for fundus autofluorescence examination, as a new
method of visualization of retinal pigment epithelium
and its possible significance in the diagnosis of
different retinal diseases.
Material and methods: Typical autofluorescence
images in age-related macular degeneration (AMD),
Stargardt disease, Best disease and pattern dystrophies
are presented, based on the own experience and
literature data. Autofluorescence images were obtained
with a cSLO using an argon laser for generation of
excitation light at 488 nm and a barrier filter >500 nm
for the detection of the emitted signals.
Results: A variety of autofluorescence patterns,
associated with the accumulation of lipofuscin in RPE
cells, was found in the above entities.
Conclusions: Presented method of fundus
autofluorescence examination gives new possibilities in
studying the pathogenetic mechanisms in various retinal
diseases and may be useful in monitoring the follow-up
and the effects of the treatment. |
| Słowa kluczowe: |
autofluorescencja,
konfokalny skaningowy oftalmoskop laserowy, lipofuscyna,
nabłonek barwnikowy siatkówki, zwyrodnienie plamki
związane z wiekiem. |
| Key words: |
autofluorescence, confocal
scanning laser ophthalmoscope, lipofuscin, retinal
pigment epithelium, age-related macular degeneration. |
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