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NR 10-12/2006
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Ocena wybranych
parametrów układu antyoksydacyjnego w erytrocytach u wcześniaków
badanych przesiewowo w kierunku ROP
The estimation of selected
parameters in antioxidant system in red blood cells in ROP
screening of premature infants
Monika Oziębło-Kupczyk1, Alina
Bakunowicz-Łazarczyk1, Krystyna Dzienis3,
Elżbieta Skrzydlewska2, Marek Szczepański3,
Ewa Waszkiewicz2
1 Z Kliniki Okulistyki Dziecięcej Akademii Medycznej
w Białymstoku
Kierownik: prof. dr hab. n. med. Alina Bakunowicz-Łazarczyk
2 Z Zakładu Chemii Analitycznej i Nieorganicznej
Akademii Medycznej w Białymstoku
Kierownik: prof. dr hab. Elżbieta Skrzydlewska
3 Z Kliniki Neonatologii Akademii Medycznej w
Białymstoku
Kierownik: dr hab. n. med. Marek Szczepański |
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| Summary: |
Purpose: To
estimate correlation between concentration of
antioxidant system parameters in red blood cells in
premature infants and prevalence of ROP.
Material and methods: We examined 16 premature
infants with the average birth weight of 1071g and
gestational age of 29.1 weeks. Supraoxide dismutase
(SOD), reduced glutatione (GSH), and glutathione
peroxidase (GSH-Px), were measured at day 1 (cord blood),
7-th and 14-th day after birth. Premature infants had
ROP screening. The control group included 12 infants
born at term.
Results: 8 premature infants had ROP. There were
higher levels of SOD, GSH and GSH-Px in premature
infants with and without ROP, than in control group.
Premature infants with ROP had lowest levels of GSH.
Conclusions: The glutathione status of red blood
cells as a oxidative stress index in premature infants
might be a reliable parameter, facilitating the early
recognition of patients in immediate danger of ROP
development. |
| Słowa kluczowe: |
retinopatia wcześniaków,
antyoksydanty, stres oksydacyjny. |
| Key words: |
retinopathy of prematurity,
antioxidants, oxidative stress. |
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