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NR 4-6/2006
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Wpływ pobudzenia
receptorów dopaminowych D1 i D2 ciał kolankowatych bocznych na
wzrokowe potencjały wywołane błyskiem u szczurów
The influence of stimulation
dopaminergic D1 i D2 receptors in lateral geniculate body by
flash visual evoked potentials (FVEP) in rats
Agata R. Plech1, Ewa Herba1,
Dorota Pojda-Wilczek1, Katarzyna
Makowiecka-Obidzińska1, Stefan M. Pojda1,
Andrzej Plech2
1 Z Katedry i Oddziału Klinicznego Okulistyki w
Bytomiu ¦l±skiej Akademii Medycznej w Katowicach
Kierownik: prof. dr hab. n. med. Stefan M. Pojda
2 Z Katedry i Zakładu Farmakologii w Zabrzu-Rokitnicy
¦l±skiej Akademii Medycznej w Katowicach
Kierownik: prof. dr hab. n. med. Ryszard Brus |
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| Summary: |
Purpose: The topic
of this paper is to define the influence of stimulation
dopaminergic D1 i D2 receptors in lateral geniculate
body by flash visual evoked potentials (FVEP).
Material and methods: Wistar rats were examined.
There were stereotaxically implanted with guide caniula
into the lateral geniculate body to inject substances
and with VEPs electrodes on the skull and on the surface
of visual cortex. VEPs curve before and after injection
into the lateral geniculate body: 0.9% NaCl, agonists of
dopamine receptors D1 – SKF 38393, and D2 Quinpirole and
also the same agonist after antagonists D1 – SCH 23390,
i D2 Sulpiride were analyzed.
Results: Stimulating receptors D1 in the lateral
geniculate body cause amplitude increase and shortness
of latency. Quinpirole, agonist of D2 receptor do not
significant change FVEPs curve.
Conclusions: Stimulation of D1receptors in the
lateral geniculate body can improve visual transmission
throught it and response in the occipital cortex. |
| Słowa kluczowe: |
wzrokowe potencjały
wywołane, ciała kolankowate boczne, dopamina, szczury. |
| Key words: |
visual evoked potentials,
lateral geniculate body, dopamine,rats. |
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