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NR 10-12/2007
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Ocena roli wybranych
cytokin w indukowaniu zmian ocznych w przebiegu zespołu suchego
oka związanego z zespołem Sjögrena
The evaluation of chosen
cytokines in induction of ocular changes in Sjögren’s syndrome
of dry eye
Nella Żywalewska-Górna, Małgorzata
Mrugacz, Alina Bakunowicz-Łazarczyk
Z Kliniki Okulistyki Dziecięcej Akademii Medycznej w Białymstoku
Kierownik Kliniki: prof. dr hab. Alina Bakunowicz-Łazarczyk |
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| Summary: |
Purpose: To
evaluate the role of pro-inflammatory cytokines
interleukin-8 (IL-8) and interferon-gamma (IFN-gamma) in
pathogenesis of Sjögren’s syndrome of dry eye (SS – dry
eye), and in induction of ocular changes in this disease.
Material and methods: Tear samples were collected
from 25 patients with Sjögren’s syndrome of dry eye and
33 healthy volunteers. Cytokine levels were determined
by ELISA. Ophthalmic examinations, including tests for
dry eye, were used to study the ocular surface. The
levels of these cytokines in tears and dry eye findings
were compared.
Results: The tears level of IL-8 and IFN-gamma in
SS – dry eye patients were significantly higher than
those in controls. We found positive correlation between
the tears levels of pro-inflammatory cytokines and dry
eye findings (subjective and objective assessments and
diagnostic tests).
Conclusions: The elevated level of
pro-inflammatory cytokines in tears fluid of patients
with Sjögren’s syndrome of dry eye may be important
factor in the pathogenesis of this disease. Significant
correlation between tears level of cytokines and dry eye
findings suggest, that these cytokines induce
inflammatory changes of ocular surface in Sjögren’s
syndrome of dry eye. |
| Słowa kluczowe: |
cytokiny, zespół Sjögrena,
płyn łzowy. |
| Key words: |
cytokines, Sjögren’s
syndrome, tear fluid. |
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