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NR 1-3/2007
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Neurohormonalna
regulacja dynamiki cieczy wodnistej jako podstawa farmakoterapii
jaskry.
Część I – Produkcja cieczy wodnistej
Neuro-hormonal regulation of
aqueous humor dynamics as the basis of glaucoma pharmacotherapy
Part I. Aqueous humor secretion
Barbara Terelak-Borys, Iwona Liberek
Z Kliniki Okulistyki Centrum Medycznego Kształcenia
Podyplomowego w Warszawie
Kierownik: dr n. med. Iwona Liberek |
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| Summary: |
The aim of this article is
to present current opinion on aqueous humor dynamics
regulation and antiglaucoma drugs mechanisms of action.
Glaucoma pharmacotherapy is based mainly on
neuro-hormonal processes controlling aqueous humor
dynamics. Systemic hormones as well as local hormones
and autonomic nervous system mediators are involved in
the processes of aqueous humor formation and drainage.
Antiglaucoma medications act mainly through activation
or inhibition of these systems’ receptors, helping to
decrease aqueous humor production or improve aqueous
humor outflow. In this article (part 1) we describe
three groups of antiglaucoma medications (beta-antagonists,
adrenergic agonists, carbonic anhydrase inhibitors),
inhibiting the aqueous humor production and mechanisms
of their hypotensive effect in the eye. |
| Słowa kluczowe: |
dynamika cieczy wodnistej,
aktywna sekrecja, ultrafiltracja, farmakoterapia jaskry,
beta-blokery, adrenomimetyki, inhibitory anhydrazy
węglanowej. |
| Key words: |
dynamics of aqueous humor,
active secretion, ultrafiltration, glaucoma
pharmacotherapy, beta-blockers, adrenergic agonists,
carbonic anhydrase inhibitors. |
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