|
NR 1-3/2007
|
|
|
|
|
|
|
|
|
Zaburzenie funkcji
bioelektrycznej siatkówki u pacjentów leczonych wigabatryną
Retinal dysfunction in
patients treated with vigabatrin
Karolina Podborączyńska-Jodko1,
Wojciech Lubiński1, Elżbieta Hampel-Osipowicz2
1 Z Katedry i Kliniki Okulistyki Pomorskiej Akademii
Medycznej w Szczecinie
Kierownik: prof. dr hab. n. med. Danuta Karczewicz
2 Z Oddziału Pediatrii i Neurologii Wieku Rozwojowego
– Szczecin Zdroje
Kierownik: dr n. med. Elżbieta Hampel-Osipowicz |
|
|
| Summary: |
Purpose: To present the
current knowledge of vigabatrin influence on the retinal
function and to introduce a case report of toxic
retinopathy diagnosed in our laboratory, in patient
treated with vigabatrin.
Material and methods: A review study based on other
authors’, concerning the role of diagnostic tests like:
perimetry, flash electroretinography (ERG), multifocal
electroretinography (mfERG), electrooculography (EOG) in
patients treated with vigabatrin and presentation of
toxic retinopathy in drug-resistant epileptic patient
treated with vigabatrin.
Results: In vigabatrin treated patients a functional or
structural retinal changes may occur, what can be
measured by electrophysiological and visual field
testing. Irreversible abnormalities of visual field and
ERG tests results prove the toxic character of
retinopathy in presented vigabatrin treated patient.
Conlusions: ERG tests and visual field assessment should
be performed in patients treated with vigabatrin.
Initial abnormalities occurrence should be a signal for
considering the change of therapy. |
| Słowa kluczowe: |
wigabatryna, siatkówka,
badania elektrofizjologiczne. |
| Key words: |
vigabatrin, retina,
electrophysiological tests. |
|
|
|
|
|
|
