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NR 4-6/2007
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Ocena związku
pomiędzy naczyniowym czynnikiem wzrostu śródbłonka (VEGF),
czynnikiem martwicy nowotworu (TNF-α), interleukiną 6 (IL-6),
wyrównaniem metabolicznym (HbA1c) a rozwojem retinopatii
cukrzycowej u dzieci z cukrzycą typu 1.
The assessment of the
correlation between vascular endothelial
growth factor (VEGF), tumor necrosis factor (TNF-α), interleukin
6 (IL-6), glycaemic control (HbA1c) and the development of the
diabetic retinopathy in children with diabetes mellitus type 1
Małgorzata Myśliwiec1, Anna
Balcerska1, Katarzyna Zorena2, Jolanta
Myśliwska2, Paweł Lipowski3, Krystyna
Raczyńska3
1 Z Kliniki Pediatrii, Hematologii, Onkologii i
Endokrynologii Akademii Medycznej w Gdańsku
Kierownik: prof. dr hab. n. med. Anna Balcerska
2 Z Zakładu Immunologii Akademii Medycznej w Gdańsku
Kierownik: prof. dr hab. n. med. Jolanta Myśliwska
3 Z Katedry i Kliniki Chorób Oczu Akademii Medycznej
w Gdańsku
Kierownik: prof. dr hab. n. med. Krystyna Raczyńska |
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| Summary: |
The aim of the work is to
assess the correlation between HbA1c, VEGF, TNF-α, IL-6
and the development of diabetic retinopathy in children
diagnosed with diabetes mellitus type 1. One hundred
fourty nine children with long-standing diabetes
mellitus type 1 were enrolled in the study. The patients
were divided into two subgroups: children with
retinopathy (Group 1; n=28) and children without
retinopathy (Group 2, n=121). The control group
consisted of 62 healthy children. All the examined
children had VEGF, TNF-α and IL-6 measured in the blood
serum using highly sensitive ELISA tests. Statistically
significant higher blood serum levels of HbA1c, VEGF,
TNF-α and IL-6 were found in the group 1 in comparison
with the group 2. Children of the group 2 in relation to
healthy controls showed statistically significant higher
blood serum levels of VEGF, TNF-α and IL-6. Elevated
levels of VEGF, TNF-α, IL-6, HbA1c in blood serum of
children with diabetes mellitus type 1 detected before
development of overt signs of diabetic retinopathy might
indicate the possibility of the occurrence of changes in
the eye shortly. |
| Słowa kluczowe: |
cukrzyca typu 1.,
retinopatia cukrzycowa, VEGF, TNF-α, IL-6. |
| Key words: |
Diabetes Mellitus type 1,
retinopathy diabetica, VEGF, TNF-α, IL-6. |
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