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NR 4-6/2007
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Interleukina-12,
naczyniowy czynnik wzrostu śródbłonka oraz czynnik martwicy
nowotworu-alpha w procesie neoangiogenezy u dzieci z retinopatią
cukrzycową
Interleukin-12, vascular
endothelial growth factor and tumor necrosis factor-alpha in the
process of neoangiogenesis of diabetic retinopathy in children
Katarzyna Zorena1, Jolanta
Myśliwska1, Małgorzata Myśliwiec2, Anna
Balcerska2, Paweł Lipowski3, Krystyna
Raczyńska3
1 Z Zakładu Immunologii Akademii Medycznej w Gdańsku
Kierownik: prof. dr hab. n. med. Jolanta Myśliwska
2 Z Oddziału Diabetologicznego Kliniki Pediatrii,
Hematologii, Onkologii i Endokrynologii Akademii Medycznej w
Gdańsku
Kierownik: prof. dr hab. n. med. Anna Balcerska
3 Z Katedry i Kliniki Chorób Oczu Akademii Medycznej
w Gdańsku
Kierownik: prof. dr hab. n. med. Krystyna Raczyńska |
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| Summary: |
Purpose: Neoangiogenesis
is a complex process, in which crucial role seems to be
played by Vascular Endothelial Growth Factor (VEGF),
Tumor Necrosis Factor-α (TNF-α) and Interleukin-12
(IL-12). Therefore it appeared to be worth of analysis
to investigate the relation between IL-12, VEGF, TNF-α
and the clinical course of the disease in children with
Diabetes Mellitus type 1 (DM1).
Material and methods: One hundred and twenty six
children in age 14.9±3.2 years diagnosed with DM1 from
the Department of Paediatrics, Haematology, Oncology and
Endocrinology of the Medical University of Gdańsk were
enrolled in the study along with 54 healthy children (as
the control). All the children had their daily urine
albumin secretion, HbA1c, C-peptide measured; 24 hrs
blood pressure monitoring and ophthalmologic examination.
Additionally, all of them had serum IL-12, VEGF, TNF-α
measured using highly-sensitive ELISA tests (Quantikine
High Sensitivity Human by R&D Systems, Minneapolis, Minn.,
USA).
Results: The children were divided into 2 groups: with
retinopathy and without retinopathy. Between the groups
statistically significant differences in age , duration
of the disease, HbA1c serum level, C-reactive protein,
daily albumin urine secretion and the systolic and
diastolic blood pressure were found. Besides,
statistically significant higher levels of VEGF, TNF-α
and IL-12 were found in the group with retinopathy in
comparison without retinopathy and healthy control group.
Conclusions: Our results suggest that VEGF, TNF-α and
IL-12 are engaged in neoangiogenesis regulation of
diabetic retinopathy children. |
| Słowa kluczowe: |
TNF, VEGF, IL-12,
angiogeneza, cukrzyca typu 1., dzieci. |
| Key words: |
TNF, VEGF, IL-12,
angiogenesis, diabetes mellitus type 1, children. |
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