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NR 4-6/2007
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Analiza zmian dna
oka w rodzinach obciążonych wysoką krótkowzrocznością
An analysis of the fundus
changes in families with high myopia
Agata Frajdenberg1, Krystyna
Pecold1, Monika Podfigurna-Musielak2,
Małgorzata Rydzanicz3, Małgorzata Mrugacz4,
Suzanne M. Leal5, Bassem A. Bejjani6,
Marzena Gajęcka3,6
1 Z Katedry i Kliniki Okulistyki Akademii Medycznej w
Poznaniu
Kierownik: dr hab. n. med. Jarosław Kocięcki
2 Z Oddziału Okulistycznego Wojewódzkiego Szpitala
Zespolonego w Lesznie
Ordynator: dr n. med. Anna Dałkowska
3 Z Instytutu Genetyki Człowieka Polskiej Akademiii
Nauk w Poznaniu, Zakład Mutagenezy
Kierownik: prof. dr hab. Krzysztof Szefter
4 Z Kliniki Okulistyki Dziecięcej Akademii Medycznej
w Białymstoku
Kierownik: prof. dr hab. n. med. Alina Bakunowicz-Łazarczyk
5 Baylor College of Medicine, Houston, Texas, USA
Head: Suzanne M. Leal M.D. Ph.D.
6 Washington State University, Spokane, Washington,
USA
Head: Prof. Bassem A. Bejjani M.D. Ph.D. |
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| Summary: |
Purpose: Of this study is
to present fundus changes in members of families with
high myopia.
Material and methods: Detailed clinical examination of
the enrolled subjects have been performed in the high
myopia families. Both affected (presented with high
myopia) and unaffected individuals (without high myopia)
are given an ophthalmologic examination: best-corrected
visual acuity testing, intraocular pressure examination,
fundoscopy, axial length determination (using
ultrasonography), refractometry.
Results: In the 19 high myopia families, 152 individuals
were carefully examined. In 11 individuals retinal
detachment have been observed. Additionally, myopic
degeneration of the central retina (15 cases),
degeneration of the peripherical retina (20 subjects),
AMD (4 subjects), hypertrophy of the RPE (2 subjects),
CNV (1 case), striae medullares (1 case) and macular
foramen (1 case), have been identified.
Conclusions:
• In the affected individuals (presented with high
myopia) changes of the eye fundus and retinal detachment
were more frequently observed comparing to unaffected
members of the families without high myopia.
• In unaffected individuals genetic factor seems to play
insignificant role in apperance of fundus
• Changes within central retina in the high myopia
individuals may conduce to severe visual impairment. |
| Słowa kluczowe: |
wysoka krótkowzroczność,
odwarstwienie siatkówki, obwodowe zmiany zwyrodnieniowe
siatkówki. |
| Key words: |
high myopia, retinal
detachment, peripherical retinal degenerations. |
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