|
NR 10-12/2008
|
|
|
|
|
|
|
|
|
Czynniki ryzyka AMD
i jaskry – obserwacje własne
Risk factors in age-related
macular degeneration and glaucoma
– own observations
Joanna Wierzbowska1,
Małgorzata Figurska1, Andrzej Stankiewicz1,
Janusz Sierdziński2
1 Z Kliniki Okulistycznej Wojskowego Instytutu
Medycznego w Warszawie
Kierownik: prof. dr hab. n. med. Andrzej Stankiewicz
2 Z Zakładu Informatyki Medycznej i Telemedycyny
Uniwersytetu Medycznego w Warszawie
Kierownik: prof. dr hab. Robert Rudowski |
|
|
| Summary: |
Purpose: To assess
the differences between the prevalence of risk factors
in patients with age- related macular degeneration (AMD),
with glaucoma and with both diseases.
Material and methods: The study included 255
patients, 156 F/99 M, in age 30 to 92 years, mean age
70.9 years. They were divided into 3 groups: AMD Group
(83 patients, 46 F/37 M, mean age 71.5), Glaucoma Group
(34 patients, 17 F/17 M, mean age 67.1) and AMD +
Glaucoma Group (138 patients, 93 F/ 45 M, mean age
70.9). In all groups age, sex, family history of AMD and
glaucoma, hypertension, hypotension,
hypercholesterolemia, diabetes, coronary heart disease,
vasospasm (cold hands), migraine, heart failure and
stroke in anamnesis, smoking, type of diet (high or low
fat intake, high or low vitamin intake), UV exposition,
cataract surgery in anamnesis, bright-coloured iris,
disc hemorrhages and peripapillary atrophy were
determined, and compared between them. T-student test,
ANOVA, Bonferoni, Kruskall-Wallis and chi-square tests
and logistic analysis (likelihood ratio chi-square) were
used for statistical analysis.
Results: Family history of glaucoma were higher
in the Glaucoma Group (odds ratio OR 9.0 p=0.004) than
in the AMD Group (odds ratio OR 9.0 p=0.004) and than in
the AMD + Glaucoma Group (OR 3.01 p=0.001). Disc
hemorrhages were higher in the Glaucoma Group (OR 13.0
p=0,020) than in the AMD Group (OR 13.0 p=0.020). High
fat intake in diet were lower in the Glaucoma Group as
compared to the AMD Group (OR 0.5 p=0,03). Cholesterol
high level and UV exposition were lower in the Glaucoma
Group than in the AMD + Glaucoma Group (OR 0.278 p=0,020
and OR 0.23 p=0,040 respectively). Coronary heart
disease and peripapillary atrophy were lower in the AMD
Group as compared to the AMD + Glaucoma Group (OR 0.43
p=0.004 and OR 0.5 p= 0.040).
Conclusions: The study has found that high fat
intake in diet was higher in the patients with AMD and
family history of glaucoma, and disc hemorrhages were
higher in the patients with glaucoma. The following risk
factors: high level of cholesterol, UV exposition,
coronary heart disease and peripapillary atrophy, were
higher in the patients with co-existing both diseases. |
| Słowa kluczowe: |
zwyrodnienie plamki
związane z wiekiem, jaskra, czynniki ryzyka. |
| Key words: |
age-related macular
degeneration, glaucoma, risk factors. |
|
|
|
|
|
|
