|
NR 10-12/2008
|
|
|
|
|
|
|
|
|
Rola układu
endokannabinoidowego w fizjologicznych i patologicznych
procesach w gałce ocznej
The role of endocannabinoid
system in physiological and pathological processes in the eye
Krystyna Nadolska, Roman Goś
Z Kliniki Okulistyki i Rehabilitacji Wzrokowej Uniwersytetu
Medycznego w Łodzi
Kierownik: prof. dr hab. n. med. Roman Goś |
|
|
| Summary: |
Plant of Cannabis sativa/
marihuana except for its psychotropic effects possesses
a range of pharmacological properties, that has been
utilized for medical purposes over a period of millenia.
Investigations concerning biochemical mechanism of
action of the main and most active pharmacological
compound of Cannabis sativa, cannabinoid Δ9-THC,
contributed to the discovery of cannabinoid receptors
both in the central nervous system (CNS) and peripheral
tissues, that mediated actions of this substance.The
discovery made possible identification of a new,
endogenous signaling system reffered to as the
endocannabinoid system. Besides cannabinoid receptors
CB1 and CB2, the system includes it’s endogenic ligands
(endocannabinoids) and compounds that participate in
their biosynthesis and inactivation. Structure and
functioning of the endocannabinoid system is
conservative in all vertebrates. It’s activation with
plant, synthetic and endogenous cannabinoids has an
influence on multiple physiological and pathological
processes within the eye. |
| Słowa kluczowe: |
Cannabis sativa,
kannabinoidy, układ endokannabinoidowy, oko. |
| Key words: |
Cannabis sativa,
cannabinoids, endocannabinoid system, the eye. |
|
|
|
|
|
|
