|
NR 7-9/2008
|
|
|
|
|
|
|
|
|
Możliwości
zastosowania kannabinoidów w leczeniu jaskry
Possibilities to apply
cannabinoids’ in the treatment of glaucoma
Krystyna Nadolska, Roman Goś
Z Kliniki Okulistyki i Rehabilitacji Wzrokowej Uniwersytetu
Medycznego w Łodzi
Kierownik: prof. dr hab. n. med. Roman Goś |
|
|
| Summary: |
Over a period of several
decades numerous scientific research has proven that,
regardless of the route of administration, cannabinoids
are able to decrease intraocular pressure. What is more,
these compounds are characterized by neuroprotection and
vasodilatation properties, that additionally
substantiate it’s therapeutic utility in conservative
treatment of glaucoma. So far, it has not been described
in details what mechanism is used to lower the
intraocular pressure by cannabinoids. Nevertheless, the
presence of endocannabinoid receptors in structures of
the eye responsible for formation and outflow of aqueous
humor is an explanation for effectiveness of these
compounds, when administered in topical form. These days,
with the aid of modern pharmacological technology are
available significantly bigger possibilities of
improving bioavailability of cannabinoids administered
to the eye than in the past, as well as limitation of
it’s undesired side effects. |
| Słowa kluczowe: |
jaskra, kannabinoidy,
potencjał terapeutyczny, mechanizm działania,
zastosowanie miejscowe. |
| Key words: |
glaucoma, cannabinoids,
therapeutic potential, mechanism of action, topical use. |
|
|
|
|
|
|
