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NR 1-3/2009
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Ocena skuteczności i
tolerancji 1,5% kropli ocznych azytromycyny w leczeniu
bakteryjnego zapalenia spojówek
Evaluation of effectiveness
and tolerance of treatment with Azithromycin 1.5% eye drops in
bacterial conjunctivitis
Anna M. Ambroziak, Jacek P. Szaflik, Adam
Hapunik
Z Katedry i Kliniki Okulistyki II Wydziału Lekarskiego
Warszawskiego Uniwersytetu Medycznego
Z Samodzielnego Publicznego Klinicznego Szpitala Okulistycznego
w Warszawie
Kierownik: prof. dr hab. n. med. Jerzy Szaflik |
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| Summary: |
Introduction:
Azithromycin is a macrolide class antibiotic, recently
adapted for topical use in ophthalmology. It is
effective against the most frequent pathogens found in
bacterial conjunctivitis, Gram positive and Gram
negative bacteria, Azithromycin has the specificity to
have sustained high tissue levels: after repeated
instillation, it has been shown to reach sustained
concentrations above the MICs of susceptible bacteria
for 4 days in tears and for 7 days in conjunctiva.
The aim of study: To investigate the
effectiveness and tolerance of treatment with
Azithromycin 1.5% eye drops in bacterial conjunctivitis.
Materials and methods: The prospective study
included 40 patients (69 eyes) with purulent bacterial
conjunctivitis; aged 21-70 years; average: 38.05
Patients were treated with 1.5% azithromycin eye drops
topically twice-dai ly for 3 days. Conjunctival swabbing
were taken at the 1st and the 7th ±1 day of the
treatment.
Effectiveness and tolerance of eye drops were assessed
in 7th ±1day from the beginning of the treatment.
Results: Bacteriological cultures were positive
before treatment in 34 eyes (49.28%), negative – 35 eyes
(50.72%).
In 69 eyes with bacterial conjunctivitis the following
microorganisms were identyfied (34 eyes):
Streptococcus pneumoniae 23.53% (8 eyes),
Staphyllococcus aureus 23.53% (8 eyes), Staphyllococcus
epidermidis 20.59%
(7 eyes), Haemophilus influenzae 17.65% (6 eyes),
Morganella Morgani 2.94% (1 eye), Proteus mirabilis
2.94% (1 eye), Enterococcus species 2.94% (1 eye),
Streptococcus viridians 2.94% (1 eye), Moraxella (Branhamella)
catarrhalis 2.94% (1 eye). Positive bacteriological
culture at the 7th day of treatment – 2 eyes (1 eye –
Staphyllococcus epidermidis MSCNS, 1 eye – Morganella
Morgani).
Clinical recovery or significant improvement were
observed in 68 of 69 evaluated eyes.
Conclusions: Three-day topical therapy with
azithromycin 1.5% eye drops is an effective and well
tolerated therapy for purulent bacterial conjunctivitis. |
| Słowa kluczowe: |
bakteryjne zapalenie
spojówek, krople oczne 1,5% azytromycyny, Azyter,
makrolidy. |
| Key words: |
purulent bacterial
conjunctivitis, topical azithromycin 1.5% eyedrops,
Azyter, macrolide. |
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