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NR 4-6/2009
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Zespół
pseudoeksfoliacji (PEX) – schorzenie ogólnoustrojowe
Pseudoexfoliation syndrome (PEX)
– a systemic disorder
Anna K. Kurowska, Anna Kamińska, Justyna
Izdebska, Jacek P. Szaflik, Jerzy Szaflik
Z Katedry i Kliniki Okulistyki II Wydziału Lekarskiego
Warszawskiego Uniwersytetu Medycznego
Z Samodzielnego Publicznego Klinicznego Szpitala Okulistycznego
w Warszawie
Kierownik: prof. dr hab. n. med. Jerzy Szaflik |
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| Summary: |
Pseudoexfoliation syndrome
is an age-related elastosis. The current pathogenetic
concept describes PEX as an elastic microfibrillopathy
involving TGF-beta1, oxidative stress and impaired
cellular protection mechanisms as a key pathogenetic
factors. Extracellular PEX material is produced,
aggregated and accumulated in the anterior segment of
the eye. It is also present in the skin, lungs, liver
and other visceral organs. These findings suggest that
pseudoexfoliation syndrome is a systemic disorder. It is
also associated with coronary artery disease,
hypertension, Alzheimer’s disease and other
cardio-vascular problems. The pseudoexfoliation syndrome
has been found to be associated with higher mean
intraocular pressure, secondary open-angle glaucoma,
mature and nuclear cataract. Ocular depositions of
pseudoexfoliation material can lead to many intraocular
complications. That’s why special attention is required
before, during and after surgery. |
| Słowa kluczowe: |
zespół pseudoeksfoliacji (PEX),
elastoza, TGF-beta1, jaskra wtórna, zaćma torebkowa,
ciśnienie wewnątrzgałkowe. |
| Key words: |
Pseudoexfoliation
syndrome, elastosis, TGF-beta1, secondary glaucoma,
nuclear cataract, intraocular pressure (IOP). |
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