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NR 7-9/2009
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Komórki macierzyste
siatkówki oka – istniejący stan badań, perspektywy terapeutyczne
Stem cells in adult retina –
current state of research, future therapeutic prospects
Anna Machalińska1,2, Ewa K.
Zuba-Surma3
1 Z Katedry i Zakładu Histologii i Embriologii
Pomorskiej Akademii Medycznej w Szczecinie
Kierownik: prof. dr hab. n. med. Barbara Wiszniewska
2 Z Zakładu Patologii Ogólnej Katedry Fizjopatologii
Pomorskiej Akademii Medycznej w Szczecinie
Kierownik: prof. dr hab. n. med. Bogusław Machaliński
3 Stem Cell Institute, James Graham Brown Cancer
Center, University of Louisville
Kierownik: prof. dr hab. n. med. Mariusz Ratajczak |
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| Summary: |
The latest research
reports revealed the presence of stem/progenitor cells
located in different regions of matured eye. They are
able to differentiate into retinal pigment epithelium
cells as well as neural structure of retina. These cells
were identified in neurosensory retina, pigment
epithelium and within cilliary body and iris epithelium.
Moreover, it has been proved that Müller glia possess
the potential of differentiation into retinal cells.
These findings indicate the presence of potential
mechanisms enabling retinal cell repopulation and
retinal tissue regeneration. In the present work, the
recent reports documenting the presence of different
stem cell populations in eye have been reviewed,
particularly focusing on recently identified very small
embryonic-like stem cells (VSEL-SCs). The potential
clinical applications of the residing stem cells and
limitations of such therapeutic strategies have been
also discussed. |
| Słowa kluczowe: |
siatkówka, komórki
macierzyste,VSEL-SC. |
| Key words: |
retina, stem cells,
VSEL-SC. |
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